Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD2 | O14939 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30797316 | 0.88 | MMP13 (0.44) | PLD2PLD1MMP13DDB1CRBN | |
| SCHEMBL17888225 | 0.86 | MMP13 (0.41) | PLD2PLD1MMP13DDB1CRBN | |
| SCHEMBL19093367 | 0.83 | LMNA (0.45) | MMP13KMT2AHSD17B10ALOX12ALDH1A1 | |
| SCHEMBL17886553 | 0.82 | OPRM1 (0.46) | PLD2PLD1MMP13DDB1CRBN | |
| SCHEMBL19095308 | 0.75 | ALDH1A1 (0.39) | PLD2PLD1MMP13DDB1CRBN | |
| SCHEMBL19095310 | 0.75 | ALDH1A1 (0.39) | PLD2PLD1MMP13DDB1CRBN | |
| SCHEMBL5095029 | 0.75 | GPR119 (0.50) | MEN1KMT2AHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL6224475 | 0.70 | MMP13 (0.40) | MMP13DDB1CRBNALOX5G6PD | |
| SCHEMBL7845062 | 0.70 | OPRK1 (0.47) | PLD2PLD1MEN1KMT2AALDH1A1 | |
| SCHEMBL22605436 | 0.69 | HSD17B10 (0.68) | HSD17B10ALDH1A1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |