Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101997 | 0.89 | ALDH1A1 (0.58) | ALDH1A1GAALMNAPOLBMAPT | |
| SCHEMBL21101771 | 0.85 | POLB (0.55) | POLB | |
| SCHEMBL21101772 | 0.84 | BRD4 (0.49) | ALDH1A1LMNAPOLBMAPTKMT2A | |
| SCHEMBL21101905 | 0.82 | ALPL (0.46) | ALDH1A1GAALMNAPOLB | |
| SCHEMBL21101911 | 0.81 | KDM4E (0.43) | ALDH1A1GAALMNAPOLB | |
| SCHEMBL23057067 | 0.81 | ALDH1A1 (0.66) | ALDH1A1GAALMNAPOLBMAPT | |
| SCHEMBL21102114 | 0.79 | LMNA (0.52) | ALDH1A1LMNAPOLBMAPTTHRB | |
| SCHEMBL10310314 | 0.78 | GAA (0.62) | ALDH1A1GAALMNAMAPTNPSR1 | |
| SCHEMBL21102111 | 0.77 | LMNA (0.59) | ALDH1A1GAALMNAMAPTKMT2A | |
| SCHEMBL21101906 | 0.77 | KDM4E (0.66) | ALDH1A1GAAMAPTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |