Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 16/20 | 0.52 |
| ▸ | CA2 | P00918 | 16/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101772 | 0.86 | BRD4 (0.49) | POLBHTTCA1CA2CTSD | |
| SCHEMBL21101904 | 0.85 | ALDH1A1 (0.60) | POLB | |
| SCHEMBL21101905 | 0.84 | ALPL (0.46) | POLB | |
| SCHEMBL21101911 | 0.83 | KDM4E (0.43) | POLBCTSD | |
| SCHEMBL21102114 | 0.81 | LMNA (0.52) | POLBCTSD | |
| SCHEMBL21102719 | 0.81 | POLB (0.63) | POLBHTTCA1CA2CA12 | |
| SCHEMBL21101932 | 0.79 | POLB (0.58) | POLBHTTCA1CA2CA12 | |
| SCHEMBL9796331 | 0.79 | POLB (0.68) | POLBHTTCA1CA2CA12 | |
| SCHEMBL21102111 | 0.79 | LMNA (0.59) | CTSD | |
| SCHEMBL21101769 | 0.79 | NPC1 (0.46) | POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |