Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101772 | 0.87 | BRD4 (0.49) | ALDH1A1NFATC1ALPLALPIBRD4 | |
| SCHEMBL21101905 | 0.85 | ALPL (0.46) | ALDH1A1GAANFATC1ALPLALPI | |
| SCHEMBL21101771 | 0.83 | POLB (0.55) | POLBCTSD | |
| SCHEMBL21102114 | 0.82 | LMNA (0.52) | KDM4EALDH1A1LMNAPOLBCTSD | |
| SCHEMBL21102111 | 0.81 | LMNA (0.59) | KDM4EALDH1A1GAALMNACTSD | |
| SCHEMBL21101904 | 0.81 | ALDH1A1 (0.60) | ALDH1A1GAALMNAPOLB | |
| SCHEMBL21101906 | 0.75 | KDM4E (0.66) | KDM4EALDH1A1GAA | |
| SCHEMBL21101769 | 0.75 | NPC1 (0.46) | ALDH1A1POLBBACE1 | |
| SCHEMBL21101778 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1LMNA | |
| SCHEMBL21101766 | 0.68 | BRD4 (0.55) | ALDH1A1GAABRD4LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |