Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101771 | 0.79 | POLB (0.55) | HTT | |
| SCHEMBL21101778 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1KMT2AMEN1HTT | |
| SCHEMBL21101772 | 0.78 | BRD4 (0.49) | ALDH1A1KMT2AMEN1HTTMAPT | |
| SCHEMBL21101904 | 0.77 | ALDH1A1 (0.60) | ALDH1A1KMT2AL3MBTL1MAPTGAA | |
| SCHEMBL21101905 | 0.76 | ALPL (0.46) | ALDH1A1GAA | |
| SCHEMBL21102114 | 0.75 | LMNA (0.52) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL21101911 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1GAA | |
| SCHEMBL21102111 | 0.73 | LMNA (0.59) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3409012 | 0.73 | TSHR (0.65) | KDM4EALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL29955875 | 0.73 | TSHR (0.65) | KDM4EALDH1A1KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |