Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849580 | 0.84 | MEN1 (0.60) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL11053847 | 0.83 | HTT (0.49) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL21116150 | 0.82 | KMT2A (0.71) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL4350367 | 0.81 | HTT (0.62) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL15786287 | 0.81 | MEN1 (0.76) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL15946354 | 0.81 | NPC1 (0.68) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL12513191 | 0.78 | ALDH1A1 (0.64) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL13756247 | 0.77 | RAB9A (0.81) | HTTMEN1KMT2ARAB9AMAPT | |
| SCHEMBL9351720 | 0.77 | IDO1 (0.58) | HTTMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL14254938 | 0.76 | L3MBTL1 (0.59) | HTTMEN1KMT2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | NATIONAL YANG-MING UNIVERSITY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | NATIONAL YANG-MING UNIVERSITY (TW) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | PRKAG1, PRKAG2, PRKAB1 | HTT 4814/4885MEN1 3893/4885KMT2A 3228/4885 |
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | PRKAG1, PRKAG2, PRKAB1 | HTT 4831/4885MEN1 3943/4885KMT2A 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.