Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PNMT | P11086 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15568736 | 1.00 | CXCL8 (0.59) | CXCL8CYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL15568192 | 1.00 | CXCL8 (0.59) | CXCL8CYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL29718684 | 0.84 | CXCL8 (0.63) | CXCL8ALDH1A1MEN1KMT2APTGS2 | |
| SCHEMBL4659044 | 0.84 | CXCL8 (0.63) | CXCL8ALDH1A1MEN1KMT2APTGS2 | |
| SCHEMBL663906 | 0.84 | CXCL8 (0.63) | CXCL8ALDH1A1MEN1KMT2APTGS2 | |
| SCHEMBL5672222 | 0.84 | CXCL8 (0.63) | CXCL8ALDH1A1MEN1KMT2APTGS2 | |
| SCHEMBL4803146 | 0.83 | CXCL8 (0.50) | CXCL8CYP1A2CYP3A4ALDH1A1LMNA | |
| SCHEMBL22969909 | 0.83 | CXCL8 (0.50) | CXCL8CYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL17513421 | 0.83 | CXCL8 (0.60) | CXCL8CYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL28342297 | 0.82 | CXCL8 (0.45) | CXCL8CYP1A2CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447134-B2 | Compounds and methods for treating mammalian gastrointestinal microbial infections | BRANDEIS UNIVERSITY (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150210727-A1 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-07-30 | — | — | US | disclosed |
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | Tokyo University of Science Educational Foundation Administration Organization (JP) | 2014-05-15 | — | — | US | disclosed |
| EP-2719679-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | Tokyo University Of Science Educational Foundation Administrative Organization (JP) | 2014-04-16 | — | — | EP | disclosed |
| WO-2014028931-A2 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | BRANDEIS UNIVERSITY (US) | 2014-02-20 | — | — | WO | disclosed |
| WO-2012168458-A1 | ZWITTERIONIC COMPOUNDS USEFUL AS CATALYSTS FOR ESTERIFICATION REACTIONS AND PROCESSES FOR THEIR PRODUCTION | ECOSYNTH BVBA (BE) | 2012-12-13 | — | — | WO | disclosed |
| US-8158633-B2 | Phenyl-substituted pyrazolopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-17 | — | — | US | disclosed |
| CN-1226294-C | Fused heteroaromatic glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-11-09 | — | — | CN | disclosed |
| US-20050119252-A1 | Ligands of melanocortin receptors and compositions and methods related thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-06-02 | — | — | US | disclosed |
| WO-2005042516-A2 | LIGANDS OF MELANOCORTIN RECEPTORS AND COMPOSITIONS AND METHODS RELATED THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-05-12 | — | — | WO | disclosed |
| CN-1476438-A | Fused heteroaromatic glucokinase activators | - | 2004-02-18 | — | — | CN | disclosed |
| US-20030114596-A1 | Thermoplastic elastomer composition and ethylene-alpha-olefin copolymer | SUMITOMO CHEMICAL COMPANY, LIMITED | 2003-06-19 | — | — | US | disclosed |
| US-6541592-B1 | An ethylene- alpha -olefin copolymer (alpha -olefin having 3 to 8 carbon atoms and content from 20-33.7wt %), Moony viscosity ML1+4100 degree C. of from 20-60, tensile stress M100 of 2.5 Mpa; excellent flexability, and processability | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-04-01 | — | — | US | disclosed |
| EP-0660024-B1 | Resin-coated pipe | SUMITOMO CHEMICAL CO (JP) | 1997-10-22 | — | — | EP | disclosed |
| US-5571585-A | HAVING EXCELLENT PROCESSABILITY, MECHANICAL STRENGTH, NORMAL AND LOW TEMPERATURE IMPACT RESISTANCE, HEAT RESISTANCE, CHIPPING RESISTANCE AND COATING SURFACE APPEEARANCE | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0660024-A1 | Resin-coated pipe | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1995-06-28 | — | — | EP | disclosed |
| EP-0593559-A1 | AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY | MERCK SHARP & DOHME LTD. (GB) | 1994-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119252-A1 | Ligands of melanocortin receptors and compositions and methods related thereto | MC3R, MC1R, MC4R | CXCL8 2239/4885CYP1A2 1024/4885CYP3A4 601/4885 |
| US-20150210727-A1 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | IMPDH1, IMPDH2, IMPA1 | CXCL8 614/4885CYP1A2 513/4885CYP3A4 563/4885 |
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | ALDH1A2, ADH1C, ADH1A | CXCL8 4618/4885CYP1A2 123/4885CYP3A4 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.