Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22468302 | 0.85 | TET2 (0.60) | SMN1; SMN2TET2TET1ALDH1A1COMT | |
| SCHEMBL22421219 | 0.82 | CYP2A6 (0.44) | ALDH1A1HSD17B10MAPTGAA | |
| SCHEMBL21508041 | 0.81 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1MAPTATM | |
| SCHEMBL22995728 | 0.81 | XDH (0.42) | SMN1; SMN2KDM4EALDH1A1HSD17B10XDH | |
| SCHEMBL22522557 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2TET2TET1ALDH1A1HSD17B10 | |
| SCHEMBL22522218 | 0.81 | XDH (0.46) | SMN1; SMN2TET2TET1ALDH1A1HSD17B10 | |
| SCHEMBL30364487 | 0.80 | FAAH (0.44) | SMN1; SMN2TET2TET1ALDH1A1MAPT | |
| SCHEMBL22234074 | 0.79 | ALDH1A1 (0.45) | SMN1; SMN2KDM4EALDH1A1XDHATM | |
| SCHEMBL22386367 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2TET2TET1ALDH1A1LCK | |
| SCHEMBL19867780 | 0.78 | GAA (0.42) | SMN1; SMN2KDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851456-B2 | P2Y6 receptor agonists for treating lung diseases | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | claimed |
| EP-1895840-A2 | P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES | Inspire Pharmaceuticals, Inc. (US) | 2008-03-12 | — | — | EP | claimed |
| US-20070015726-A1 | P2Y6 receptor agonists for treating lung diseases | MERCK SHARP & DOHME LLC | 2007-01-18 | — | — | US | claimed |
| WO-2007002945-A2 | P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES | INSPIRE PHARMACEUTICALS, INC. (US) | 2007-01-04 | — | — | WO | claimed |
| US-20230295119-A1 | SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GOSSAMER BIO SERVICES INC (US) | 2023-09-21 | — | — | US | disclosed |
| US-20230295119-A1 | SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GOSSAMER BIO SERVICES INC (US) | 2023-09-21 | — | — | US | disclosed |
| US-20230278987-A1 | Antimicrobial Compounds and Methods | CURZA GLOBAL, LLC. | 2023-09-07 | — | — | US | disclosed |
| US-20230159491-A1 | Antimicrobial Compounds and Methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
| EP-4136073-A1 | SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | Gossamer Bio Services, Inc. (US) | 2023-02-22 | — | — | EP | disclosed |
| CN-115702145-A | Substituted pyridines for the treatment of inflammatory diseases | 戈萨默生物服务公司 | 2023-02-14 | — | — | CN | disclosed |
| WO-2021211741-A1 | SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GOSSAMER BIO SERVICES, INC. (US) | 2021-10-21 | — | — | WO | disclosed |
| WO-2021211741-A1 | SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GOSSAMER BIO SERVICES, INC. (US) | 2021-10-21 | — | — | WO | disclosed |
| US-20200316069-A1 | CYTOSINE-BASED TET ENZYME INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-08 | — | — | US | disclosed |
| WO-2018048937-A1 | 2'-SUBSTITUTED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR RNA VIRUS TREATMENT | Atea Pharmaceuticals, Inc. (US) | 2018-03-15 | — | — | WO | disclosed |
| US-8158776-B2 | P2Y6 receptor agonists for treating lung diseases | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20110054163-A1 | P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES | MERCK SHARP & DOHME LLC | 2011-03-03 | — | — | US | disclosed |
| US-7851456-B2 | P2Y6 receptor agonists for treating lung diseases | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| EP-1895840-A2 | P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES | Inspire Pharmaceuticals, Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20070015726-A1 | P2Y6 receptor agonists for treating lung diseases | MERCK SHARP & DOHME LLC | 2007-01-18 | — | — | US | disclosed |
| WO-2007002945-A2 | P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES | INSPIRE PHARMACEUTICALS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110054163-A1 | P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES | P2RY6, P2RY1, P2RY11 | SMN1; SMN2 3522/4885DDB1 3460/4885CRBN 4858/4885 |
| US-20200316069-A1 | CYTOSINE-BASED TET ENZYME INHIBITORS | TET1, TET3, TET2 | SMN1; SMN2 2787/4885DDB1 229/4885CRBN 718/4885 |
| US-20230278987-A1 | Antimicrobial Compounds and Methods | CLPP, RPN2, MPO | SMN1; SMN2 4805/4885DDB1 704/4885CRBN 4243/4885 |
| US-20230295119-A1 | SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | IRAK3, TYK2, IRAK2 | SMN1; SMN2 2846/4885DDB1 3827/4885CRBN 1808/4885 |
| US-20230159491-A1 | Antimicrobial Compounds and Methods | MPO, NISCH, RPN2 | SMN1; SMN2 4817/4885DDB1 973/4885CRBN 4074/4885 |
| US-20070015726-A1 | P2Y6 receptor agonists for treating lung diseases | P2RY6, P2RY1, P2RY11 | SMN1; SMN2 3373/4885DDB1 3497/4885CRBN 4864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.