Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.38 |
| ▸ | USP19 | O94966 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170326 | 0.87 | TRPV3 (0.49) | MEN1KMT2AL3MBTL1MAPTPOLB | |
| SCHEMBL21170451 | 0.86 | MKNK2 (0.48) | TRPV3MAPK1 | |
| SCHEMBL21170447 | 0.86 | HPGD (0.45) | MEN1KMT2AL3MBTL1MAPTPOLB | |
| SCHEMBL12287801 | 0.85 | CRBN (0.45) | CRBNMEN1KMT2ALMNAEPHX2 | |
| SCHEMBL21170095 | 0.79 | TP53BP1 (0.39) | POLB | |
| SCHEMBL12287289 | 0.79 | DPP4 (0.42) | MEN1KMT2A | |
| SCHEMBL21170038 | 0.79 | DPP4 (0.42) | MEN1KMT2A | |
| SCHEMBL12287723 | 0.79 | DPP4 (0.42) | MEN1KMT2A | |
| SCHEMBL21170091 | 0.78 | MAP4K4 (0.38) | MEN1KMT2AMAPT | |
| SCHEMBL21170185 | 0.78 | TRPM8 (0.41) | MEN1KMT2ALMNAMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |