Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CBLB | Q13191 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170326 | 0.91 | TRPV3 (0.49) | TRPV3PARP1MAPK1 | |
| SCHEMBL21170447 | 0.90 | HPGD (0.45) | TRPV3PARP1MAPK1 | |
| SCHEMBL21170039 | 0.86 | CRBN (0.44) | TRPV3MAPK1 | |
| SCHEMBL2565340 | 0.82 | MKNK2 (0.48) | MKNK2MKNK1NTRK1ATRCCNC | |
| SCHEMBL12287289 | 0.82 | DPP4 (0.42) | PARP1 | |
| SCHEMBL12287723 | 0.82 | DPP4 (0.42) | PARP1 | |
| SCHEMBL21170038 | 0.82 | DPP4 (0.42) | PARP1 | |
| SCHEMBL21170185 | 0.81 | TRPM8 (0.41) | MAPK1 | |
| SCHEMBL21170091 | 0.81 | MAP4K4 (0.38) | CDK8 | |
| SCHEMBL21170174 | 0.78 | GPR52 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |