Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170326 | 0.91 | TRPV3 (0.49) | HPGDMAPTPOLBRAB9ANPC1 | |
| SCHEMBL21170451 | 0.90 | MKNK2 (0.48) | PARP1TRPV3MAPK1 | |
| SCHEMBL21170039 | 0.86 | CRBN (0.44) | MAPTPOLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL12289914 | 0.82 | HPGD (0.45) | HPGDMAPTPOLBPKMMAPK14 | |
| SCHEMBL12287723 | 0.82 | DPP4 (0.42) | MAPK14RAB9ANPC1PARP1MEN1 | |
| SCHEMBL12287289 | 0.82 | DPP4 (0.42) | MAPK14RAB9ANPC1PARP1MEN1 | |
| SCHEMBL21170038 | 0.82 | DPP4 (0.42) | MAPK14RAB9ANPC1PARP1MEN1 | |
| SCHEMBL21170185 | 0.81 | TRPM8 (0.41) | HPGDMAPTMAPK14RAB9ANPC1 | |
| SCHEMBL21170091 | 0.81 | MAP4K4 (0.38) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL21170174 | 0.78 | GPR52 (0.42) | MAPK14MAP4K4ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |