Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 7/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 5/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10052155 | 0.85 | ENPP3 (0.45) | ENPP3ENPP1HSD11B1MEN1KMT2A | |
| SCHEMBL6668389 | 0.82 | ENPP3 (0.43) | ENPP3ENPP1HSD11B1MEN1KMT2A | |
| SCHEMBL30765909 | 0.82 | ENPP3 (0.43) | ENPP3ENPP1HSD11B1MEN1KMT2A | |
| SCHEMBL13848629 | 0.79 | ENPP3 (0.44) | ENPP3ENPP1HSD11B1MEN1KMT2A | |
| SCHEMBL13744630 | 0.77 | ENPP3 (0.42) | ENPP3ENPP1HSD11B1MEN1KMT2A | |
| SCHEMBL30003076 | 0.74 | PGR (0.40) | ENPP3ENPP1HSD11B1ALDH1A1DAGLA | |
| SCHEMBL2265105 | 0.71 | ENPP3 (0.68) | ENPP3ENPP1HSD11B1MEN1KMT2A | |
| SCHEMBL31558543 | 0.70 | HSD11B1 (0.35) | ENPP3ENPP1HSD11B1MEN1KMT2A | |
| SCHEMBL17516272 | 0.69 | ENPP3 (0.59) | ENPP3ENPP1MEN1KMT2ARAB9A | |
| SCHEMBL278182 | 0.69 | ENPP3 (0.69) | ENPP3ENPP1HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10358427-B2 | Modulators of indoleamine 2,3-dioxygenase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358427-B2 | Modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, INMT | ENPP3 892/4885ENPP1 1115/4885HSD11B1 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.