Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28180374 | 0.83 | ALDH1A1 (0.36) | NFKB1NFKB2RELARAB9AMIF | |
| SCHEMBL19490023 | 0.71 | NFKB1 (0.37) | NFKB1NFKB2RELAGAACA1 | |
| SCHEMBL6822199 | 0.66 | NFKB1 (0.38) | NFKB1NFKB2RELARAB9AGAA | |
| SCHEMBL31363878 | 0.64 | DRD2 (0.36) | NFKB1NFKB2RELADRD2LIPE | |
| SCHEMBL1438907 | 0.64 | LMNA (0.37) | NFKB1NFKB2RELARAB9AGAA | |
| SCHEMBL31258505 | 0.63 | NFKB1 (0.35) | NFKB1NFKB2RELACA1CA2 | |
| SCHEMBL1656241 | 0.61 | NFKB1 (0.41) | NFKB1NFKB2RELADRD2GAA | |
| SCHEMBL13055402 | 0.61 | CYP17A1 (0.59) | DRD2LIPEGAACA1ALDH1A1 | |
| SCHEMBL15264820 | 0.61 | ATR (0.48) | NFKB1NFKB2RELARAB9AGAA | |
| SCHEMBL3410364 | 0.61 | HPGD (0.49) | ALDH1A1POLBBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884050-B | Tetrahydroisoquinoline derivatives | UCB生物制药私人有限公司 | 2022-07-05 | — | — | CN | disclosed |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2019-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | GPR52, GRK3, GPR3 | NFKB1 2090/4885NFKB2 1392/4885RELA 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.