Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241854 | 0.92 | MAPT (0.48) | MAPTPHGDHCSNK2A1NPC1GAA | |
| SCHEMBL21242061 | 0.92 | POLB (0.52) | MAPTL3MBTL1POLBSMN1; SMN2NPC1 | |
| SCHEMBL21241931 | 0.92 | MAPT (0.55) | MAPTNPC1GAARAB9AMEN1 | |
| SCHEMBL21241888 | 0.87 | MAPT (0.40) | MAPTL3MBTL1POLBSMN1; SMN2MEN1 | |
| SCHEMBL21241795 | 0.87 | MAPT (0.45) | MAPTROCK1POLBSMN1; SMN2NPC1 | |
| SCHEMBL21241887 | 0.86 | SIRT5 (0.41) | MAPTPOLBSIRT5SMN1; SMN2NPSR1 | |
| SCHEMBL21241981 | 0.85 | ADORA3 (0.54) | MAPTL3MBTL1POLBSMN1; SMN2GAA | |
| SCHEMBL21241794 | 0.84 | RAB9A (0.44) | MAPTROCK2ROCK1POLBSMN1; SMN2 | |
| SCHEMBL21224293 | 0.83 | MAPT (0.55) | MAPTPHGDHROCK1SMN1; SMN2NPC1 | |
| SCHEMBL24511284 | 0.82 | PDE5A (0.48) | MAPTPOLBNPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |