Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | WNT3A | P56704 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21242061 | 0.91 | POLB (0.52) | MAPTLMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL21241931 | 0.91 | MAPT (0.55) | MAPTKMT2AALDH1A1MEN1ELOVL1 | |
| SCHEMBL21241794 | 0.91 | RAB9A (0.44) | MAPTLMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL21241854 | 0.88 | MAPT (0.48) | MAPTKMT2AALDH1A1MEN1ELOVL1 | |
| SCHEMBL21241789 | 0.87 | MAPT (0.47) | MAPTSMN1; SMN2POLBKMT2AROCK1 | |
| SCHEMBL21241888 | 0.86 | MAPT (0.40) | MAPTLMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL21241981 | 0.84 | ADORA3 (0.54) | MAPTLMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL21225009 | 0.83 | ALDH1A1 (0.51) | MAPTLMNASMN1; SMN2KMT2AWNT3A | |
| SCHEMBL21241887 | 0.83 | SIRT5 (0.41) | MAPTLMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL21241803 | 0.81 | CSNK2A2 (0.41) | LMNAKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |