Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KDM4A | O75164 | 4/20 | 0.54 |
| ▸ | KDM4B | O94953 | 4/20 | 0.54 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.54 |
| ▸ | KDM5C | P41229 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241931 | 0.89 | MAPT (0.55) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL21241887 | 0.86 | SIRT5 (0.41) | ALDH1A1MAPTPOLBKDM4ETDP1 | |
| SCHEMBL21241888 | 0.86 | MAPT (0.40) | ALDH1A1MAPTPOLBKDM4ELMNA | |
| SCHEMBL21242061 | 0.85 | POLB (0.52) | ALDH1A1MAPTPOLBKDM4EGAA | |
| SCHEMBL21241854 | 0.85 | MAPT (0.48) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL21241789 | 0.85 | MAPT (0.47) | MAPTPOLBGAAMEN1KMT2A | |
| SCHEMBL21241795 | 0.84 | MAPT (0.45) | ALDH1A1MAPTPOLBLMNAMEN1 | |
| SCHEMBL21241947 | 0.83 | ADORA3 (0.53) | ADORA3ALDH1A1MAPTPOLBKDM4E | |
| SCHEMBL21224200 | 0.83 | KDM4A (0.65) | ADORA3ALDH1A1MAPTPOLBKDM4E | |
| SCHEMBL21241803 | 0.82 | CSNK2A2 (0.41) | LMNAMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |