Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.59 |
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871990 | 0.84 | ALDH5A1 (0.53) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL6990311 | 0.83 | CES2 (0.64) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL6990314 | 0.83 | CES2 (0.64) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL13977393 | 0.82 | HDAC1 (0.56) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL8836296 | 0.82 | KDM4E (0.49) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL14192544 | 0.82 | KDM4E (0.57) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL8780278 | 0.81 | CES2 (0.61) | CES2CES1KMT2AMEN1MAPT | |
| Water SCHEMBL3522042 | 0.79 | CES2 (0.59) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL5262647 | 0.78 | CES2 (0.56) | CES2CES1KMT2AMEN1MAPT | |
| SCHEMBL20007006 | 0.78 | HTT (0.65) | KMT2AMEN1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105576138-B | Platinum (II) isoquinoline-pyridine-benzene-based complex, preparation method thereof and organic light emitting diode prepared therefrom | 港大科桥有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-104926788-A | Substituted piperidin derivative, and pharmaceutical composition containing substituted piperidin derivative and application thereof in antitumor | UNIV ZHEJIANG | 2015-09-23 | — | — | CN | disclosed |
| EP-2443132-A1 | PLATINUM (II) ISOQUINOLINE-PYRIDINE-BENZENE BASED COMPLEXES, PREPARING METHOD THEREOF, AND ORGANIC LIGHT-EMITTING DIODES MADE THEREFROM | Versitech Limited (CN) | 2012-04-25 | — | — | EP | disclosed |
| WO-2011109470-A1 | HETEROARYL NITRILE COMPOUNDS USEFUL AS INHIBITORS OF CATHEPSIN-S | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-09 | — | — | WO | disclosed |
| WO-2010145190-A1 | PLATINUM (II) ISOQUINOLINE-PYRIDINE-BENZENE BASED COMPLEXES, PREPARING METHOD THEREOF, AND ORGANIC LIGHT-EMITTING DIODES MADE THEREFROM | THE UNIVERSITY OF HONG KONG (CN) | 2010-12-23 | — | — | WO | disclosed |
| CN-101730703-A | Benzamide derivatives with antiproliferative activity and pharmaceutical preparations thereof | RADIATION MEDICINE OF PLA MILI | 2010-06-09 | — | — | CN | disclosed |
| US-20070161646-A1 | Piperidine Derivatives and Their Use as Modulators of Chemokine Receptor Activity (Especially CCR5) | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
| US-7192973-B2 | Piperidine derivatives and their use as modulators of chemokine receptor activity (especially CCR5) | ASTRAZENECA AB (SE) | 2007-03-20 | — | — | US | disclosed |
| US-20040267016-A1 | Piperidine derivatives and their use as modulators of chemokine receptor activity (especially ccr5) | ASTRAZENECA AB (SE) | 2004-12-30 | — | — | US | disclosed |
| EP-1448548-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY (ESPECIALLY CCR5) | AstraZeneca AB (SE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003042205-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY (ESPECIALLY CCR5) | ASTRAZENECA AB (SE) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040267016-A1 | Piperidine derivatives and their use as modulators of chemokine receptor activity (especially ccr5) | CCR5, CCR2, CCR1 | CES2 665/4885CES1 954/4885KMT2A 4487/4885 |
| US-20070161646-A1 | Piperidine Derivatives and Their Use as Modulators of Chemokine Receptor Activity (Especially CCR5) | CCR5, CCR2, CCL5 | CES2 647/4885CES1 1248/4885KMT2A 4465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.