SCHEMBL21297748

SCHEMBL21297748

Cc1c(C)c2nccnc2c2cncnc12

nearest known ligand 0.43

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.43
HSP90AA1 P07900 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CCR1 P32246 2/20 0.35
CCR5 P51681 2/20 0.35
CCR8 P51685 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21297742 0.92 NPC1 (0.43) NPC1HSP90AA1L3MBTL1CCR1CCR5
SCHEMBL19623115 0.85 CCR1 (0.33) NPC1HSP90AA1L3MBTL1CCR1CCR5
SCHEMBL16345858 0.84 HSP90AA1 (0.36) NPC1HSP90AA1L3MBTL1CCR1CCR5
SCHEMBL29397266 0.84 HSP90AA1 (0.36) NPC1HSP90AA1L3MBTL1CCR1CCR5
SCHEMBL29399777 0.84 HSP90AA1 (0.36) NPC1HSP90AA1L3MBTL1CCR1CCR5
Fluoromethane SCHEMBL28912319 0.83 HSP90AA1 (0.37) NPC1HSP90AA1L3MBTL1CCR1CCR5
Methane SCHEMBL28329646 0.82 HSP90AA1 (0.34) NPC1HSP90AA1L3MBTL1CCR1CCR5
SCHEMBL19060941 0.81 L3MBTL1 (0.62) NPC1HSP90AA1L3MBTL1CCR1CCR5
SCHEMBL21297856 0.77 L3MBTL1 (0.57) NPC1HSP90AA1L3MBTL1CCR1CCR5
SCHEMBL21297866 0.76 KIT (0.37) NPC1HSP90AA1L3MBTL1CCR1CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-11063228-B2 Metal-assisted delayed fluorescent emitters employing benzo-imidazo-phenanthridine and analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2021-07-13 US disclosed
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2021-01-28 US disclosed
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-12-01 US disclosed
US-20200119288-A1 Metal-Assisted Delayed Fluorescent Emitters Employing Benzo-imidazo-phenanthridine and Analogues UNITED STATES DEPARTMENT OF ENERGY 2020-04-16 US disclosed
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2020-03-05 US disclosed
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS NPC1 4076/4885HSP90AA1 226/4885L3MBTL1 661/4885
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS NPC1 4076/4885HSP90AA1 226/4885L3MBTL1 661/4885
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS NPC1 4076/4885HSP90AA1 226/4885L3MBTL1 661/4885
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials KCNK4, TRPC4, TBRG4 NPC1 4601/4885HSP90AA1 1287/4885L3MBTL1 1758/4885
US-20200119288-A1 Metal-Assisted Delayed Fluorescent Emitters Employing Benzo-imidazo-phenanthridine and Analogues IK, HELZ, SUN2 NPC1 3036/4885HSP90AA1 2330/4885L3MBTL1 1734/4885
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials NT5C, HTR3D, IK NPC1 2661/4885HSP90AA1 773/4885L3MBTL1 1948/4885
US-11063228-B2 Metal-assisted delayed fluorescent emitters employing benzo-imidazo-phenanthridine and analogues IK, HELZ, SUN2 NPC1 3036/4885HSP90AA1 2330/4885L3MBTL1 1734/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.