Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23031867 | 0.80 | CA2 (0.43) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL22815269 | 0.79 | KDM1A (0.48) | — | |
| SCHEMBL23031880 | 0.78 | ALDH1A1 (0.35) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23031869 | 0.78 | PARP1 (0.36) | HDAC6 | |
| SCHEMBL13978225 | 0.77 | HDAC3 (0.40) | LOXL2F10HDAC3HDAC6NCOR2 | |
| SCHEMBL22043779 | 0.77 | CYP2D6 (0.47) | HDAC6PLAU | |
| SCHEMBL22044273 | 0.77 | GRIN2B (0.44) | NOS3NOS1PLAU | |
| SCHEMBL18891357 | 0.76 | KMT2A (0.48) | F10F2 | |
| SCHEMBL23031878 | 0.76 | LMNA (0.44) | — | |
| SCHEMBL23734498 | 0.76 | NOS1 (0.55) | LOXL2F10HDAC3HDAC6NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361098-B1 | COMPOSITIONS AND METHODS FOR DELIVERING A SUBSTANCE TO A BIOLOGICAL TARGET | MASSACHUSETTS GEN HOSPITAL (US) | 2019-08-28 | — | — | EP | disclosed |