Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664746 | 0.90 | ALOX12 (0.45) | DGKAALOX12SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL23922917 | 0.86 | ALOX12 (0.42) | DGKAALOX12SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL8744647 | 0.86 | ALOX12 (0.46) | DGKAALOX12SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL3109237 | 0.84 | DGKA (0.40) | DGKASMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL28236067 | 0.79 | ALOX12 (0.41) | ALOX12SMN1; SMN2MAPK1KDM4EPOLB | |
| SCHEMBL4698358 | 0.78 | PRKCA (0.39) | DGKAALOX12MAPK1ALDH1A1GAA | |
| SCHEMBL4696895 | 0.78 | DGKA (0.38) | DGKASMN1; SMN2MAPK1ALDH1A1GAA | |
| SCHEMBL20786977 | 0.78 | ALOX12 (0.43) | ALOX12SMN1; SMN2MAPK1KDM4EPOLB | |
| SCHEMBL24777173 | 0.78 | ALDH1A1 (0.45) | DGKASMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL25499775 | 0.78 | ALOX12 (0.45) | DGKAALOX12SMN1; SMN2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539570-B1 | PEGYLATED ENDOSTATIN ANALOGUE AND APPLICATION THEREOF | BEIJING PROTGEN LTD (CN) | 2022-04-13 | — | — | EP | claimed |
| US-20200270333-A1 | PEGYLATED ENDOSTATIN ANALOGUE AND APPLICATION THEREOF | BEIJING PROTGEN LTD. (CN) | 2020-08-27 | — | — | US | claimed |
| EP-3539570-A1 | PEGYLATED ENDOSTATIN ANALOGUE AND APPLICATION THEREOF | Beijing Protgen Ltd. (CN) | 2019-09-18 | — | — | EP | claimed |
| CN-108893454-A | Polyethyleneglycol modified recombination glutathione peroxidase GPx1 mutant, preparation method and anti-oxidant application | 吉林大学 | 2018-11-27 | — | — | CN | claimed |
| EP-3539570-B1 | PEGYLATED ENDOSTATIN ANALOGUE AND APPLICATION THEREOF | BEIJING PROTGEN LTD (CN) | 2022-04-13 | — | — | EP | disclosed |
| US-20200270333-A1 | PEGYLATED ENDOSTATIN ANALOGUE AND APPLICATION THEREOF | BEIJING PROTGEN LTD. (CN) | 2020-08-27 | — | — | US | disclosed |
| EP-3539570-A1 | PEGYLATED ENDOSTATIN ANALOGUE AND APPLICATION THEREOF | Beijing Protgen Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |