Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18348139 | 0.87 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1UCHL1CXCR2PDE4A | |
| SCHEMBL17452560 | 0.82 | UCHL1 (0.41) | UCHL1CXCR2MEN1KMT2AALDH1A1 | |
| SCHEMBL21359074 | 0.81 | HSP90AA1 (0.36) | MLYCDHSP90AA1HSP90AB1UCHL1CLK1 | |
| SCHEMBL570468 | 0.77 | P4HB (0.47) | MLYCDP4HBDGAT1 | |
| SCHEMBL2741830 | 0.75 | P4HB (0.43) | MLYCDCLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL18340042 | 0.73 | ERN1 (0.39) | HSP90AA1HSP90AB1UCHL1MEN1KMT2A | |
| SCHEMBL21361324 | 0.73 | MLYCD (0.43) | MLYCDHSP90AA1HSP90AB1CLK1DYRK1A | |
| SCHEMBL31111473 | 0.72 | HSD17B3 (0.37) | UCHL1CXCR2HIF1A | |
| SCHEMBL204977 | 0.72 | CXCR2 (0.39) | UCHL1CXCR2MEN1KMT2AALDH1A1 | |
| SCHEMBL17707756 | 0.72 | CXCR2 (0.39) | UCHL1CXCR2PDE4BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2022-04-07 | — | — | US | disclosed |
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2022-04-07 | — | — | US | disclosed |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2022-04-07 | — | — | US | disclosed |
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-02-08 | — | — | US | disclosed |
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-02-08 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| CN-112292124-A | Bicyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2021-01-29 | — | — | CN | disclosed |
| EP-3765009-A1 | BICYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences, BV (US) | 2021-01-20 | — | — | EP | disclosed |
| EP-3765020-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences B.V. (US) | 2021-01-20 | — | — | EP | disclosed |
| CN-112118841-A | Spirocyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2020-12-22 | — | — | CN | disclosed |
| WO-2019177996-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
| WO-2019177997-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
| WO-2019177997-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | RORA, RORC, RORB | MLYCD 4092/4885HSP90AA1 854/4885HSP90AB1 830/4885 |
| US-11230555-B2 | Bicyclic RORγ modulators | RORC, RORA, RORB | MLYCD 3627/4885HSP90AA1 1901/4885HSP90AB1 1680/4885 |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 3583/4885HSP90AA1 1903/4885HSP90AB1 1768/4885 |
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 4092/4885HSP90AA1 854/4885HSP90AB1 830/4885 |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 4180/4885HSP90AA1 649/4885HSP90AB1 693/4885 |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 3583/4885HSP90AA1 1903/4885HSP90AB1 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.