Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002841 | 0.87 | MLYCD (0.39) | TRPM8MLYCDMTORPIK3CACLK1 | |
| SCHEMBL23003364 | 0.85 | PTPN1 (0.36) | TRPM8MLYCDMTORPIK3CACLK1 | |
| SCHEMBL23003346 | 0.83 | HSP90AA1 (0.43) | TRPM8GPR119 | |
| SCHEMBL18075678 | 0.81 | KMT2A (0.36) | TRPM8MLYCDMTORPIK3CACLK1 | |
| SCHEMBL2845005 | 0.81 | LMNA (0.40) | MLYCDMTORPIK3CACLK1DYRK1A | |
| SCHEMBL15918563 | 0.79 | SLC6A3 (0.43) | TRPM8MLYCDMTORPIK3CACLK1 | |
| SCHEMBL23003420 | 0.78 | PDK2 (0.42) | TRPM8MLYCDMTORPIK3CALMNA | |
| SCHEMBL31103821 | 0.78 | KMT2A (0.36) | TRPM8MLYCDMTORPIK3CACLK1 | |
| SCHEMBL12345357 | 0.78 | CA12 (0.42) | TRPM8MLYCDMTORCLK1DYRK1A | |
| SCHEMBL21374047 | 0.77 | TRPM8 (0.35) | TRPM8MLYCDMTORPIK3CACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2022-04-07 | — | — | US | disclosed |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2022-04-07 | — | — | US | disclosed |
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-02-08 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| CN-112292124-A | Bicyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112118841-A | Spirocyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2020-12-22 | — | — | CN | disclosed |
| WO-2019177996-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | RORA, RORC, RORB | TRPM8 2052/4885MLYCD 4092/4885MTOR 3295/4885 |
| US-11230555-B2 | Bicyclic RORγ modulators | RORC, RORA, RORB | TRPM8 2241/4885MLYCD 3627/4885MTOR 3237/4885 |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | TRPM8 2438/4885MLYCD 3583/4885MTOR 3776/4885 |
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | TRPM8 2052/4885MLYCD 4092/4885MTOR 3295/4885 |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | TRPM8 1562/4885MLYCD 4180/4885MTOR 2955/4885 |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | TRPM8 2438/4885MLYCD 3583/4885MTOR 3776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.