Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28452277 | 0.87 | ALDH1A1 (0.53) | L3MBTL1MAPK1GAAPOLBDRD2 | |
| SCHEMBL21384617 | 0.83 | L3MBTL1 (0.51) | L3MBTL1MAPK1GAAPOLBDRD2 | |
| SCHEMBL4435638 | 0.81 | ITGB3 (0.46) | — | |
| SCHEMBL11120035 | 0.79 | L3MBTL1 (0.47) | L3MBTL1MAPK1GAAPOLBALDH1A1 | |
| SCHEMBL21384573 | 0.77 | ALDH1A1 (0.54) | L3MBTL1MAPK1GAAPOLBDRD2 | |
| SCHEMBL21397276 | 0.77 | DRD2 (0.51) | L3MBTL1MAPK1GAAPOLBDRD2 | |
| SCHEMBL2074046 | 0.77 | GAA (0.64) | L3MBTL1MAPK1GAAPOLBALDH1A1 | |
| SCHEMBL12988256 | 0.76 | HTR3E (0.54) | L3MBTL1MAPK1GAAPOLBDRD2 | |
| Hydrochloric Acid SCHEMBL21385163 | 0.76 | DRD2 (0.50) | L3MBTL1MAPK1GAAPOLBDRD2 | |
| SCHEMBL1976988 | 0.75 | AKR1C3 (0.46) | MAPTKMT2AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117185987-A | Amidine and guanidine derivatives, preparation method and medical application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-111630048-B | Amidine and guanidine derivatives, preparation method and medical application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-111630048-A | Amidine and guanidine derivatives, preparation method and application thereof in medicines | 四川科伦博泰生物医药股份有限公司 | 2020-09-04 | — | — | CN | disclosed |
| WO-2019179362-A1 | AMIDINE AND GUANIDINE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USES THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-09-26 | — | — | WO | disclosed |
| WO-2019179362-A1 | AMIDINE AND GUANIDINE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USES THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-09-26 | — | — | WO | disclosed |