Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 12/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387693 | 0.77 | SYK (0.43) | SYKHRH4HRH3 | |
| SCHEMBL21381593 | 0.76 | CTPS1 (0.51) | — | |
| SCHEMBL21387600 | 0.74 | CTPS1 (0.31) | TAS2R14SYK | |
| SCHEMBL21387636 | 0.74 | CTPS1 (0.39) | — | |
| SCHEMBL21387714 | 0.72 | CTPS1 (0.41) | SYK | |
| SCHEMBL21387595 | 0.69 | CTPS1 (0.32) | SYK | |
| SCHEMBL17420494 | 0.68 | HSP90AA1 (0.38) | TAS2R14HRH4 | |
| SCHEMBL23121276 | 0.68 | ALOX15 (0.40) | TAS2R14 | |
| SCHEMBL21392238 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL13369675 | 0.67 | TAS2R14 (0.57) | TAS2R14SYKPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019180244-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |