Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 3/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390925 | 0.91 | HPGDS (0.34) | HDAC3PTGS1HDAC4HDAC1HDAC2 | |
| SCHEMBL21391179 | 0.89 | ACSS2 (0.33) | HDAC3PTGS1HDAC4HDAC1HDAC2 | |
| SCHEMBL21391182 | 0.87 | PDE2A (0.31) | ALOX5AP | |
| SCHEMBL21390820 | 0.87 | ACSS2 (0.33) | HDAC3HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL21390821 | 0.84 | PDE2A (0.30) | ALOX5AP | |
| SCHEMBL21390681 | 0.83 | BRD4 (0.35) | BRD4HDAC3PTGS1HDAC4HDAC1 | |
| SCHEMBL21390670 | 0.83 | TRPV4 (0.35) | IDH1 | |
| SCHEMBL21391016 | 0.82 | HDAC1 (0.36) | BRD4HDAC1IDH1 | |
| SCHEMBL23132028 | 0.80 | BRD4 (0.35) | BRD4HDAC3PTGS1HDAC4HDAC1 | |
| SCHEMBL21390680 | 0.79 | HDAC1 (0.36) | BRD4HDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |