Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390758 | 0.90 | HTR3A (0.31) | NOS1NOS2 | |
| SCHEMBL21391168 | 0.81 | RORC (0.35) | — | |
| SCHEMBL21390920 | 0.79 | RORC (0.33) | — | |
| SCHEMBL21391137 | 0.79 | AGTR2 (0.34) | PDE2APDE5APDE1BPDE4BPDE4D | |
| SCHEMBL19276123 | 0.77 | NOS1 (0.34) | NOS1NOS2CNR2POLBPDE4B | |
| SCHEMBL21390857 | 0.77 | RORC (0.32) | — | |
| SCHEMBL21390774 | 0.76 | RORC (0.41) | POLB | |
| SCHEMBL21391074 | 0.76 | RORC (0.30) | — | |
| SCHEMBL21391064 | 0.75 | RORC (0.37) | — | |
| SCHEMBL21391073 | 0.75 | PDE10A (0.37) | PDE2APDE5APDE4DPDE7APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |