Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391079 | 0.97 | CYP19A1 (0.32) | CYP19A1CYP11B1CYP11B2RORCJAK1 | |
| SCHEMBL21390808 | 0.83 | JAK2 (0.33) | RORCJAK1JAK2TYK2JAK3 | |
| SCHEMBL21390929 | 0.82 | RORC (0.30) | RORC | |
| SCHEMBL21391078 | 0.79 | KDM4E (0.33) | JAK1JAK2TYK2JAK3HDAC1 | |
| SCHEMBL21390893 | 0.79 | RORC (0.31) | RORC | |
| SCHEMBL21390815 | 0.78 | HDAC1 (0.33) | RORCJAK1HDAC1 | |
| SCHEMBL23132031 | 0.77 | CYP11B2 (0.41) | CYP19A1CYP11B1CYP11B2HDAC1 | |
| SCHEMBL21390819 | 0.76 | CNR2 (0.32) | RORCJAK1HDAC1 | |
| SCHEMBL21390880 | 0.75 | HDAC1 (0.37) | RORCHDAC1 | |
| SCHEMBL21391086 | 0.74 | AR (0.33) | JAK1JAK2TYK2JAK3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |