SCHEMBL2139104

SCHEMBL2139104

Cc1ccc(C)c(-c2nc3ccccc3s2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.57
NPC1 O15118 6/20 0.57
RAB9A P51151 6/20 0.57
KDM4E B2RXH2 5/20 0.57
SMN1; SMN2 Q16637 5/20 0.57
ALDH1A1 P00352 4/20 0.57
GAA P10253 4/20 0.57
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
TDP1 Q9NUW8 3/20 0.57
L3MBTL1 Q9Y468 3/20 0.57
GLA P06280 2/20 0.54
HCRTR1 O43613 1/20 0.54
ILK Q13418 1/20 0.54
AGPAT2 O15120 1/20 0.53
NPSR1 Q6W5P4 2/20 0.53
RXFP1 Q9HBX9 1/20 0.52
LMNA P02545 2/20 0.51
NFKB1 P19838 1/20 0.51
NFKB2 Q00653 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10414016 0.86 KDM4E (0.64) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL25327971 0.84 MAPT (0.71) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL29478092 0.84 MAPT (0.71) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL2790890 0.84 MAPT (0.69) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL27769428 0.83 MAPT (0.68) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL2137490 0.83 KDM4E (0.69) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL7197286 0.83 MAPT (0.72) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL28957331 0.83 MAPT (0.55) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL25329016 0.83 MAPT (0.69) MAPTNPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL30211740 0.83 MAPT (0.69) MAPTNPC1RAB9AKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230212136-A1 CURABLE RESIN COMPOSITION, CURED PRODUCT, DIFFRACTIVE OPTICAL ELEMENT, AND MULTILAYER DIFFRACTIVE OPTICAL ELEMENT FUJIFILM CORPORATION (JP) 2023-07-06 US disclosed
US-20230212136-A1 CURABLE RESIN COMPOSITION, CURED PRODUCT, DIFFRACTIVE OPTICAL ELEMENT, AND MULTILAYER DIFFRACTIVE OPTICAL ELEMENT FUJIFILM CORPORATION (JP) 2023-07-06 US disclosed
US-10301328-B2 Organoboron compounds and methods of making same Lu, Jiasheng (CN) 2019-05-28 US disclosed
US-10301328-B2 Organoboron compounds and methods of making same Lu, Jiasheng (CN) 2019-05-28 US disclosed
US-9500790-B2 Optical film, circularly polarizing plate, and image display device Konica Minolta, Inc. (JP) 2016-11-22 US disclosed
US-20160046652-A1 Organoboron Compounds and Methods of Making Same LU, Jiasheng (CN) 2016-02-18 US disclosed
US-20160046652-A1 Organoboron Compounds and Methods of Making Same LU, Jiasheng (CN) 2016-02-18 US disclosed
US-20160046652-A1 Organoboron Compounds and Methods of Making Same LU, Jiasheng (CN) 2016-02-18 US disclosed
US-20150247963-A1 OPTICAL FILM, CIRCULARLY POLARIZING PLATE, AND IMAGE DISPLAY DEVICE Konica Minolta, Inc. (JP) 2015-09-03 US disclosed
WO-2014153648-A1 ORGANOBORON COMPOUNDS AND METHODS OF MAKING SAME LU JIASHENG 2014-10-02 WO disclosed
US-8242278-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-14 US disclosed
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI (JP) 2012-04-26 US disclosed
EP-1473286-B1 PROCESS FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL CO (JP) 2009-11-04 EP disclosed
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI 2009-08-27 US disclosed
US-7554000-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-30 US disclosed
US-20050096471-A1 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-05-05 US disclosed
EP-1473286-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-03 EP disclosed
US-4892921-A LIQUID CRYSTAL POLYMERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1990-01-09 US disclosed
US-4835246-A Pendant benzazole rigid-rod aromatic heterocyclic polymer THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1989-05-30 US disclosed
US-4785115-A INTERMEDIATES FOR HETEROCYCLIC POLYMERS OF COMPRESSIVE STRENGTH THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE UNITED STATES (US) 1988-11-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR MAPT 3403/4885NPC1 4102/4885RAB9A 2254/4885
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR MAPT 3403/4885NPC1 4102/4885RAB9A 2254/4885
US-20230212136-A1 CURABLE RESIN COMPOSITION, CURED PRODUCT, DIFFRACTIVE OPTICAL ELEMENT, AND MULTILAYER DIFFRACTIVE OPTICAL ELEMENT TERB1, RER1, LARP1 MAPT 655/4885NPC1 1492/4885RAB9A 2669/4885
US-20150247963-A1 OPTICAL FILM, CIRCULARLY POLARIZING PLATE, AND IMAGE DISPLAY DEVICE SUN2, HTR3D, CRY1 MAPT 1692/4885NPC1 1653/4885RAB9A 2452/4885
US-20050096471-A1 Process for producing biaryl compound PPOX, CAT, TYR MAPT 3403/4885NPC1 4102/4885RAB9A 2254/4885
US-10301328-B2 Organoboron compounds and methods of making same NISCH, CCKBR, TBCB MAPT 4120/4885NPC1 1605/4885RAB9A 1941/4885
US-20160046652-A1 Organoboron Compounds and Methods of Making Same NISCH, CCKBR, TBCB MAPT 4120/4885NPC1 1605/4885RAB9A 1941/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.