Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392320 | 0.86 | USP2 (0.35) | RAB9AUSP2TSHRARPTGER2 | |
| SCHEMBL21392152 | 0.85 | PTPN1 (0.36) | PTGER2ALDH1A1DYRK1ALMNAMAPT | |
| SCHEMBL30415860 | 0.85 | PTPN1 (0.36) | PTGER2ALDH1A1DYRK1ALMNAMAPT | |
| SCHEMBL26977404 | 0.82 | AR (0.35) | RAB9AARKDM4EALDH1A1GAA | |
| SCHEMBL21392075 | 0.79 | ALDH1A1 (0.35) | USP2TSHRALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28477374 | 0.76 | CASP6 (0.41) | RAB9AARSMN1; SMN2GAAKMT2A | |
| SCHEMBL21373801 | 0.75 | AAK1 (0.36) | DYRK1A | |
| SCHEMBL21392292 | 0.71 | ALDH1A1 (0.35) | USP2TSHRARPTGER2CACNA1B | |
| SCHEMBL30725707 | 0.71 | PTPN1 (0.39) | USP2TSHRPTGER2ALDH1A1LMNA | |
| SCHEMBL21384620 | 0.71 | PTPN1 (0.39) | USP2TSHRPTGER2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019180244-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |