Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA4 | P22748 | 3/20 | 0.47 |
| ▸ | CA6 | P23280 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | TPMT | P51580 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28625696 | 0.92 | LCK (0.55) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL1505272 | 0.89 | LCK (0.62) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL12444087 | 0.88 | ALDH1A1 (0.56) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL6704966 | 0.88 | LCK (0.60) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL13596372 | 0.88 | ALDH1A1 (0.56) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL27476490 | 0.84 | HTT (0.53) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL13434226 | 0.84 | HTT (0.55) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL1753958 | 0.83 | HTT (0.52) | ALDH1A1HPGDKDM4ECA9HSD17B10 | |
| SCHEMBL16200306 | 0.82 | ALDH1A1 (0.47) | LCKFYNALDH1A1HPGDKDM4E | |
| SCHEMBL7019995 | 0.82 | KDM4E (0.53) | LCKFYNALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729095-B2 | 3-(biaryloxy)propionic acid derivatives for prevention and/or treatment of thromboembolic diseases | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-05-20 | — | — | US | disclosed |
| US-8629271-B2 | Compounds | ASTRAZENECA AB (GB) | 2014-01-14 | — | — | US | disclosed |
| US-20120322788-A1 | Compouds | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-12-20 | — | — | US | disclosed |
| US-20120245152-A1 | 3-(BIARYOXY)PROPIONIC ACID DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-09-27 | — | — | US | disclosed |
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| EP-2471792-A1 | 3-(BIARYLOXY) PROPIONIC ACID DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-07-04 | — | — | EP | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| EP-2242759-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2010-10-27 | — | — | EP | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| WO-2009098448-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245152-A1 | 3-(BIARYOXY)PROPIONIC ACID DERIVATIVE | F11, PF4, F2 | LCK 4052/4885FYN 248/4885ALDH1A1 793/4885 |
| US-20120322788-A1 | Compouds | PKD1, SBDS, ABCB11 | LCK 4729/4885FYN 4512/4885ALDH1A1 155/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | LCK 3602/4885FYN 3190/4885ALDH1A1 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.