Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 9/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21403277 | 0.88 | EGLN1 (0.44) | EGLN1KDM5AKDM4CKDM5BPDE1B | |
| SCHEMBL8520898 | 0.84 | EGLN1 (0.42) | EGLN1KDM5BPDE1B | |
| SCHEMBL8529005 | 0.79 | EGLN1 (0.47) | EGLN1BBOX1ASPHKDM8 | |
| SCHEMBL30812491 | 0.78 | EGLN1 (0.49) | EGLN1KDM5AKDM4CKDM5BPDE1B | |
| Enarodustat SCHEMBL21403278 | 0.76 | EGLN1 (0.53) | EGLN1BBOX1ASPHKDM8 | |
| SCHEMBL21416114 | 0.74 | EGLN1 (0.36) | EGLN1KDM5AKDM4CKDM5BPDE1B | |
| Enarodustat SCHEMBL1481440 | 0.72 | EGLN1 (0.64) | EGLN1BBOX1ASPHKDM8 | |
| Enarodustat SCHEMBL21403279 | 0.71 | EGLN1 (0.63) | EGLN1BBOX1ASPHKDM8 | |
| Hydrochloric Acid SCHEMBL1482465 | 0.69 | EGLN1 (0.47) | EGLN1BBOX1ASPHKDM8 | |
| Hydrochloric Acid SCHEMBL1482548 | 0.69 | EGLN1 (0.47) | EGLN1BBOX1ASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11434238-B2 | Method for producing triazolopyridine compound | JAPAN TOBACCO INC. (JP) | 2022-09-06 | — | — | US | disclosed |
| CN-110214139-B | Process for producing triazolopyridine compound | 日本烟草产业株式会社 | 2022-08-23 | — | — | CN | disclosed |
| US-20200339563-A1 | METHOD FOR PRODUCING TRIAZOLOPYRIDINE COMPOUND | SHIONOGI & CO., LTD. (JP) | 2020-10-29 | — | — | US | disclosed |
| EP-3546459-A1 | METHOD FOR PRODUCING TRIAZOLOPYRIDINE COMPOUND | Japan Tobacco, Inc. (JP) | 2019-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339563-A1 | METHOD FOR PRODUCING TRIAZOLOPYRIDINE COMPOUND | EPOR, PAH, THPO | EGLN1 13/4885KDM5A 44/4885KDM4C 515/4885 |
| US-11434238-B2 | Method for producing triazolopyridine compound | EPOR, PAH, THPO | EGLN1 13/4885KDM5A 44/4885KDM4C 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.