SCHEMBL21425

SCHEMBL21425

[O]CC(F)(F)C(F)(F)C(F)(F)C(F)F

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.38
KDM4E B2RXH2 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
USP2 O75604 1/20 0.31
MAPT P10636 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10638134 0.92 TSHR (0.37) TSHRKDM4ETDP1USP2MAPT
SCHEMBL6897374 0.90 TSHR (0.39) TSHRKDM4ETDP1USP2MAPT
SCHEMBL6897341 0.90 TSHR (0.39) TSHRKDM4ETDP1USP2MAPT
SCHEMBL186999 0.82 KDM4E (0.31) TSHRKDM4ETDP1
SCHEMBL5494860 0.78 KDM4E (0.33) TSHRKDM4ETDP1CYP1A2CYP2C19
SCHEMBL1535878 0.75
SCHEMBL1358616 0.74 KDM4E (0.34) TSHRKDM4ETDP1CYP1A2CYP2C19
SCHEMBL10868933 0.74 KDM4E (0.31) TSHRKDM4ETDP1
SCHEMBL21426 0.72 TSHR (0.38) TSHRKDM4ETDP1USP2MAPT
SCHEMBL22117322 0.72 KDM4E (0.33) TSHRKDM4ETDP1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10750742-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-08-25 US claimed
US-20200048238-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-02-13 US claimed
EP-3606918-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2020-02-12 EP claimed
US-20190014783-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-01-17 US claimed
EP-3393245-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2018-10-31 EP claimed
WO-2018185187-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2018-10-11 WO claimed
WO-2017108569-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-06-29 WO claimed
US-9040457-B2 Phenylamidines having a high fungicidal activity and use thereof ISAGRO S.P.A. (IT) 2015-05-26 US claimed
US-20130157851-A1 PHENYLAMIDINES HAVING A HIGH FUNGICIDAL ACTIVITY AND USE THEREOF ISAGRO S.P.A. (IT) 2013-06-20 US claimed
EP-0567982-B1 Azole compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-07-01 EP claimed
US-5213880-A Radiaition transparent conductive layer of indium tin oxide and a curable phosphazine IDEMITSU PETROCHEMICAL COMPANY, LIMITED (JP) 1993-05-25 US claimed
US-11993578-B2 Pyrazole-3-carboxylic acid amide derivative and pest control agent KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2024-05-28 US disclosed
EP-4371979-A1 FORMAMIDE DERIVATIVE AND AGRICULTURAL OR HORTICULTURAL PLANT DISEASE CONTROL AGENT Kumiai Chemical Industry Co., Ltd. (JP) 2024-05-22 EP disclosed
US-11964957-B2 Pyrazole derivative and harmful organism-controlling agent KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2024-04-23 US disclosed
EP-3808738-B1 PYRAZOLE DERIVATIVE AND HARMFUL ORGANISM-CONTROLLING AGENT KUMIAI CHEMICAL INDUSTRY CO (JP) 2024-04-17 EP disclosed
EP-0446961-A2 Stabilized pharmaceutical composition and its production Takeda Chemical Industries, Ltd. (JP) 1991-09-18 EP disclosed
US-5045321-A Antiulcer compound lansoprazole or omeprazole with magnesium and/or calcium salt; tablets or granules TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1991-09-03 US disclosed
EP-0443626-A2 Electrophotographic photosensensitive member IDEMITSU PETROCHEMICAL CO. LTD. (JP) 1991-08-28 EP disclosed
EP-0423748-A1 Stabilized pharmaceutical composition and its production Takeda Chemical Industries, Ltd. (JP) 1991-04-24 EP disclosed
EP-0237200-A2 Use of basic inorganic salts of magnesium or calcium for the stabilisation of benzimidazole derivatives Takeda Chemical Industries, Ltd. (JP) 1987-09-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11964957-B2 Pyrazole derivative and harmful organism-controlling agent L3MBTL3, L3MBTL1, L3MBTL4 TSHR 870/4885KDM4E 1473/4885TDP1 3190/4885
US-11993578-B2 Pyrazole-3-carboxylic acid amide derivative and pest control agent H1-3, HDAC3, H1-0 TSHR 297/4885KDM4E 3999/4885TDP1 3693/4885
US-20190014783-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES ACHE, AADAC, CAT TSHR 3444/4885KDM4E 2949/4885TDP1 2880/4885
US-20130157851-A1 PHENYLAMIDINES HAVING A HIGH FUNGICIDAL ACTIVITY AND USE THEREOF PAH, DPM1, PFAS TSHR 4320/4885KDM4E 1854/4885TDP1 884/4885
US-10750742-B2 Pesticidally active pyrazole derivatives ACHE, AADAC, CAT TSHR 3444/4885KDM4E 2949/4885TDP1 2880/4885
US-20200048238-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES ACHE, AADAC, CAT TSHR 3621/4885KDM4E 2972/4885TDP1 2766/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.