Sugi Predict

Sugi Predict / Compounds / Acacetin

Acacetin

Acacetin

SCHEMBL2146352

COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1.O=c1cc(-c2ccccc2)oc2ccccc12

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.79
▸ CYP3A4 P08684 6/20 0.79
▸ MEN1 O00255 6/20 0.79
▸ KMT2A Q03164 6/20 0.79
▸ CYP1B1 Q16678 6/20 0.79
▸ MAOB P27338 5/20 0.79
▸ CYP2C9 P11712 5/20 0.79
▸ CYP2C19 P33261 5/20 0.79
▸ NPC1 O15118 5/20 0.79
▸ TP53 P04637 5/20 0.79
▸ ALDH1A1 P00352 5/20 0.79
▸ CYP1A1 P04798 5/20 0.79
▸ CYP1A2 P05177 5/20 0.79
▸ SMN1; SMN2 Q16637 4/20 0.79
▸ IP6K2 Q9UHH9 4/20 0.79
▸ RAB9A P51151 3/20 0.79
▸ LMNA P02545 3/20 0.79
▸ CYP2D6 P10635 3/20 0.79
▸ MAOA P21397 3/20 0.79
▸ MAPK1 P28482 3/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Genkwanin SCHEMBL2464219 0.91 CYP3A4 (0.80) MAPTCYP3A4MEN1KMT2ACYP1B1
Chrysin SCHEMBL3858957 0.90 ABCB1 (0.84) MAPTCYP3A4MEN1KMT2ACYP1B1
Apigenin SCHEMBL3430874 0.89 CYP3A4 (0.78) MAPTCYP3A4MEN1KMT2ACYP1B1
Acacetin SCHEMBL107712 0.89 CYP1B1 (1.00) MAPTCYP3A4MEN1KMT2ACYP1B1
Acacetin SCHEMBL29387049 0.89 CYP1B1 (1.00) MAPTCYP3A4MEN1KMT2ACYP1B1
Diosmetin SCHEMBL19127636 0.89 CYP1B1 (0.78) MAPTCYP3A4MEN1KMT2ACYP1B1
Acacetin SCHEMBL28278297 0.88 CYP1B1 (0.97) MAPTCYP3A4MEN1KMT2ACYP1B1
Tricin SCHEMBL20719977 0.88 MAOA (0.76) MAPTCYP3A4MEN1KMT2ACYP1B1
Luteolin SCHEMBL1229732 0.86 POLH (0.75) MAPTCYP3A4MEN1KMT2ACYP1B1
Luteolin SCHEMBL15271260 0.86 POLH (0.75) MAPTCYP3A4MEN1KMT2ACYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104011054-B As the thieno of potassium channel inhibitors and Furanopyrimidines class and pyridines 森申有限公司 2016-08-24 — — CN disclosed
US-20160152634-A1 THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS XENTION LTD (GB) 2016-06-02 — — US disclosed
US-9290511-B2 Thieno-pyrimidines, useful as potassium channel inhibitors XENTION LIMITED (GB) 2016-03-22 — — US disclosed
US-20140371203-A1 Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors XENTION LIMITED (GB) 2014-12-18 — — US disclosed
US-20140357662-A1 THIENO (2,3 - C) PYRAZOLES FOR USE AS POTASSIUM CHANNEL INHIBITORS XENTION LIMITED (GB) 2014-12-04 — — US disclosed
EP-2780343-A1 THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS Xention Limited (GB) 2014-09-24 — — EP disclosed
EP-2780344-A1 THIENO [2, 3 - C]PYRAZOLES FOR USE AS POTASSIUM CHANNEL INHIBITORS Xention Limited (GB) 2014-09-24 — — EP disclosed
US-8461198-B2 Use of acacetin and related compounds as potassium channel inhibitors VERSITECH LIMITED (CN) 2013-06-11 — — US disclosed
WO-2013072693-A1 THIENO [2, 3 - C] PYRAZOLES FOR USE AS POTASSIUM CHANNEL INHIBITORS XENTION LIMITED (GB) 2013-05-23 — — WO disclosed
WO-2013072694-A1 THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS XENTION LIMITED (GB) 2013-05-23 — — WO disclosed
EP-2523701-A1 STABLE HYDROGEL COMPOSITIONS INCLUDING ADDITIVES Allergan Industrie, SAS (FR) 2012-11-21 — — EP disclosed
CN-101273984-B Use of flavone compounds as potassium channel inhibitors UNIV HONG KONG 2012-10-10 — — CN disclosed
WO-2011086458-A1 STABLE HYDROGEL COMPOSITIONS INCLUDING ADDITIVES ALLERGAN INDUSTRIE, SAS (FR) 2011-07-21 — — WO disclosed
US-20100331271-A1 Use of Acacetin and Related Compounds as Potassium Channel Inhibitors VERSITECH LIMITED (CN) 2010-12-30 — — US disclosed
US-7816400-B2 Use of acacetin and related compounds as potassium channel inhibitors THE UNIVERSITY OF HONG KONG (CN) 2010-10-19 — — US disclosed
US-20080214493-A1 Use of Flavone Compounds as Potassium Channel Inhibitors VERSITECH LIMITED (CN) 2008-09-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140371203-A1 Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors KCNA3, KCNJ1, KCNJ11 MAPT 2780/4885CYP3A4 682/4885MEN1 1141/4885
US-20160152634-A1 THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS KCNA3, KCNJ1, KCNJ11 MAPT 2726/4885CYP3A4 556/4885MEN1 1205/4885
US-20100331271-A1 Use of Acacetin and Related Compounds as Potassium Channel Inhibitors KCNH1, KCNN2, KCNN3 MAPT 1613/4885CYP3A4 958/4885MEN1 2366/4885
US-20080214493-A1 Use of Flavone Compounds as Potassium Channel Inhibitors KCNN3, KCNN2, KCNN1 MAPT 2027/4885CYP3A4 1072/4885MEN1 2831/4885
US-20140357662-A1 THIENO (2,3 - C) PYRAZOLES FOR USE AS POTASSIUM CHANNEL INHIBITORS KCNA3, KCNK3, KCNJ1 MAPT 3320/4885CYP3A4 381/4885MEN1 1429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.