Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.41 |
| ▸ | MAP1LC3A | Q9H492 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165394 | 0.82 | GABRA1 (0.50) | OPRK1MAP1LC3BMAP1LC3AHDAC4HDAC2 | |
| SCHEMBL18091143 | 0.80 | CNR1 (0.50) | DAOHTTALDH1A1HPGDDRD2 | |
| SCHEMBL9579004 | 0.79 | OPRM1 (0.50) | OPRM1OPRK1OPRD1MAP1LC3BMAP1LC3A | |
| SCHEMBL18091153 | 0.79 | CNR1 (0.48) | DAOHTTALDH1A1HPGDDRD2 | |
| SCHEMBL18091148 | 0.79 | CNR1 (0.48) | DAOHTTALDH1A1HPGDDRD2 | |
| SCHEMBL18091149 | 0.79 | CNR1 (0.48) | DAOHTTALDH1A1HPGDDRD2 | |
| SCHEMBL18091141 | 0.79 | CNR1 (0.48) | DAOHTTALDH1A1HPGDDRD2 | |
| SCHEMBL18091152 | 0.79 | CNR1 (0.48) | DAOHTTALDH1A1HPGDDRD2 | |
| SCHEMBL18378383 | 0.79 | CNR1 (0.48) | DAOHTTALDH1A1HPGDDRD2 | |
| SCHEMBL104012 | 0.78 | OPRK1 (0.70) | OPRM1OPRK1OPRD1DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163393-A1 | HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2021-06-03 | — | — | US | disclosed |
| EP-3773900-A2 | HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF | The Board of Trustees of the University of Illinois (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019200314-A2 | HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163393-A1 | HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF | CYP27A1, CYP27B1, HSD17B7 | OPRM1 2931/4885OPRK1 1023/4885OPRD1 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.