Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 14/20 | 0.67 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.48 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.48 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14407819 | 0.83 | FKBP1A (0.65) | FKBP1AABCC1FKBP4FKBP5SMN1; SMN2 | |
| SCHEMBL7155851 | 0.81 | FKBP1A (0.80) | FKBP1AABCC1FKBP4FKBP5 | |
| SCHEMBL5966161 | 0.81 | FKBP1A (0.80) | FKBP1AABCC1FKBP4FKBP5 | |
| SCHEMBL21540139 | 0.81 | SIGMAR1 (0.52) | FKBP1ASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL17884418 | 0.78 | FKBP5 (0.52) | FKBP1AFKBP5ALDH1A1 | |
| SCHEMBL1233420 | 0.78 | FKBP1A (0.74) | FKBP1AABCC1FKBP4FKBP5 | |
| SCHEMBL1233422 | 0.78 | FKBP1A (0.74) | FKBP1AABCC1FKBP4FKBP5 | |
| SCHEMBL21540176 | 0.77 | FKBP5 (0.67) | FKBP1AFKBP4FKBP5TDP1 | |
| SCHEMBL8186423 | 0.76 | ALDH1A1 (0.66) | FKBP1ASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL19337360 | 0.75 | FKBP1A (0.48) | FKBP1AFKBP5TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3007696-B1 | NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF | UNIV TEXAS (US) | 2019-10-16 | — | — | EP | disclosed |