Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076182 | 0.70 | CRBN (0.41) | ALDH1A1CASP3PGR | |
| SCHEMBL21477060 | 0.70 | CRBN (0.41) | ALDH1A1CASP3PGR | |
| SCHEMBL17169696 | 0.69 | MMP2 (0.46) | ALDH1A1CASP3MMP9MEN1KMT2A | |
| SCHEMBL715099 | 0.67 | MMP9 (0.51) | ALDH1A1POLBMMP9MEN1KMT2A | |
| SCHEMBL11285990 | 0.64 | MMP9 (0.44) | MMP9GAA | |
| Allobarbital SCHEMBL35976 | 0.63 | LMNA (0.48) | ALDH1A1MMP9GAAMMP13 | |
| SCHEMBL2047434 | 0.63 | PGR (0.44) | ALDH1A1CASP3PGRNPSR1CA12 | |
| SCHEMBL170913 | 0.63 | CASP3 (0.85) | ALDH1A1CASP3POLBNPSR1CA12 | |
| SCHEMBL31377051 | 0.63 | CASP3 (0.85) | ALDH1A1CASP3POLBNPSR1CA12 | |
| Allobarbital SCHEMBL3642549 | 0.62 | MMP2 (0.47) | ALDH1A1POLBMMP9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-B1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS INC (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2019199816-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |