SCHEMBL715099

SCHEMBL715099

C=CCC1(c2ccccc2)C(=O)NC(=O)NC1=O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 8/20 0.51
MMP2 P08253 7/20 0.51
MMP3 P08254 4/20 0.51
MMP13 P45452 2/20 0.49
CACNA1F O60840 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
CYP2C9 P11712 1/20 0.43
HTR2A P28223 1/20 0.43
HRH1 P35367 1/20 0.43
SCN1A P35498 1/20 0.43
SCN4A P35499 1/20 0.43
BLM P54132 1/20 0.43
PMP22 Q01453 1/20 0.43
CACNA1D Q01668 1/20 0.43
KCNH2 Q12809 1/20 0.43
CACNA1S Q13698 1/20 0.43
CACNA1C Q13936 1/20 0.43
SCN5A Q14524 1/20 0.43
SCN2A Q99250 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Allobarbital SCHEMBL3642549 0.94 MMP2 (0.47) MMP9MMP2MMP3MMP13CACNA1F
Phenobarbital SCHEMBL7618451 0.92 MMP9 (0.63) MMP9MMP2MMP3MMP13LMNA
SCHEMBL32689845 0.87 KMT2A (0.42) MMP9MMP2MMP3MMP13CACNA1F
SCHEMBL11278266 0.84 MMP9 (0.53) MMP9MMP2MMP3MMP13CACNA1F
SCHEMBL23959035 0.80 LMNA (0.51) MMP9MMP2MMP3KCNH2LMNA
SCHEMBL11406274 0.77 MMP9 (0.50) MMP9MMP2MMP3MMP13CACNA1F
SCHEMBL4384790 0.77 GABRA1 (0.40) MMP9MMP2MMP3MMP13MAPT
Phenobarbital SCHEMBL22719965 0.76 MMP2 (0.75) MMP9MMP2MMP3MMP13CACNA1F
Phenobarbital SCHEMBL18222943 0.76 MMP9 (0.63) MMP9MMP2MMP3MMP13LMNA
Phenobarbital SCHEMBL16583 0.76 MMP2 (0.80) MMP9MMP2MMP3MMP13CACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 727 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260041939-A1 METHODS FOR THE TREATMENT OF HYPERTENSION VIA TRANSCRANIAL-FOCUSED-ULTRASOUND SUNNYBROOK RES INST (CA) 2026-02-12 US claimed
US-12161695-B2 GABA A receptor agonists for treatment of disorders influenced by dysfunction BETA cells DIAMYD MEDICAL AB (SE) 2024-12-10 US claimed
US-11839615-B2 Compounds and methods for treating addiction and related disorders ASTROCYTE PHARMACEUTICALS, INC. (US) 2023-12-12 US claimed
US-20210113586-A1 NEW USE AND METHODS OF MODULATING IMMUNE RESPONSES DIAMYD MEDICAL AB (SE) 2021-04-22 US claimed
US-20210030760-A1 COMPOUNDS AND METHODS FOR TREATING ADDICTION AND RELATED DISORDERS ASTROCYTE PHARMACEUTICALS, INC. 2021-02-04 US claimed
EP-3756007-A1 NEW USE AND METHODS OF MODULATING IMMUNE RESPONSES Diamyd Medical AB (SE) 2020-12-30 EP claimed
EP-3755314-A1 GABA A RECEPTOR AGONISTS FOR TREATMENT OF DISORDERS INFLUENCED BY DYSFUNCTION BETA CELLS Diamyd Medical AB (SE) 2020-12-30 EP claimed
EP-3749322-A1 COMPOUNDS AND METHODS FOR TREATING ADDICTION AND RELATED DISORDERS Astrocyte Pharmaceuticals, Inc. (US) 2020-12-16 EP claimed
US-20200384086-A1 GABA A RECEPTOR AGONISTS FOR TREATMENT OF DISORDERS INFLUENCED BY DYSFUNCTION BETA CELLS DIAMYD MEDICAL AB (SE) 2020-12-10 US claimed
US-20200138830-A1 ENHANCING GABA'S ABILITY TO MODULATE IMMUNE RESPONSES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-05-07 US claimed
WO-2006127024-A1 REAGENTS AND METHODS FOR LABELING TERMINAL OLEFINS EISAI CO. LTD. (JP) 2006-11-30 WO claimed
US-20060045846-A1 Reagents and methods for labeling terminal olefins EISAI R&D MANAGEMENT CO., LTD. (JP) 2006-03-02 US claimed
WO-2002006826-B1 SINGLE-PATIENT DRUG TRIALS USED WITH ACCUMULATED DATABASE OPT E SCRIP INC (US) 2002-04-04 WO claimed
US-20020032581-A1 Single-patient drug trials used with accumulated database: risk of habituation OPT-E-SCRIP, INC. 2002-03-14 US claimed
WO-2002006826-A1 SINGLE-PATIENT DRUG TRIALS USED WITH ACCUMULATED DATABASE OPT-E-SCRIP, INC. (US) 2002-01-24 WO claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-1027609-A2 METHOD FOR DETERMINATION OF DRUGS OF ABUSE IN BIOLOGICAL SAMPLES Varian, Inc. (US) 2000-08-16 EP claimed
WO-1999022244-A2 METHOD FOR DETERMINATION OF DRUGS OF ABUSE IN BIOLOGICAL SAMPLES VARIAN, INC. (US) 1999-05-06 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11839615-B2 Compounds and methods for treating addiction and related disorders ADORA2A, TAAR5, ADORA3 MMP9 4015/4885MMP2 3603/4885MMP3 2861/4885
US-20260041939-A1 METHODS FOR THE TREATMENT OF HYPERTENSION VIA TRANSCRANIAL-FOCUSED-ULTRASOUND FABP7, FABP3, ADRB2 MMP9 1199/4885MMP2 1438/4885MMP3 1651/4885
US-20210030760-A1 COMPOUNDS AND METHODS FOR TREATING ADDICTION AND RELATED DISORDERS SLC6A3, PNMT, CES2 MMP9 3124/4885MMP2 3280/4885MMP3 2446/4885
US-20060045846-A1 Reagents and methods for labeling terminal olefins EEF2, RNF168, REL MMP9 4827/4885MMP2 3808/4885MMP3 4219/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.