SCHEMBL2153234

SCHEMBL2153234

CS(=O)(Cc1ccc(C(F)F)nc1)=NC#N

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 10/20 0.36
CDK9 P50750 10/20 0.36
HDAC6 Q9UBN7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9610888 0.80 CDK2 (0.39) CDK2CDK9
SCHEMBL121954 0.79 ALDH1A1 (0.43) CDK2CDK9
SCHEMBL18231808 0.79 CDK2 (0.36) CDK2CDK9
SCHEMBL119494 0.78 CDK2 (0.39) CDK2CDK9
SCHEMBL9610902 0.77 CDK2 (0.37) CDK2CDK9HDAC6
SCHEMBL13899231 0.77 CDK2 (0.41) CDK2CDK9
SCHEMBL2153112 0.77 CDK2 (0.36) CDK2CDK9
SCHEMBL2471526 0.73 PDE9A (0.32)
SCHEMBL17804548 0.72 PDE9A (0.31)
SCHEMBL3285457 0.70 CDK2 (0.43) CDK2CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3120701-B1 STABLE SULFOXIMINE-INSECTICIDE COMPOSITIONS DOW AGROSCIENCES LLC (US) 2019-08-28 EP disclosed
EP-3120701-A1 STABLE SULFOXIMINE-INSECTICIDE COMPOSITIONS Dow AgroSciences LLC (US) 2017-01-25 EP disclosed
EP-3120701-A1 STABLE SULFOXIMINE-INSECTICIDE COMPOSITIONS Dow AgroSciences LLC (US) 2017-01-25 EP disclosed
EP-2369935-B1 STABLE INSECTICIDE COMPOSITIONS AND METHODS FOR PRODUCING SAME DOW AGROSCIENCES LLC (US) 2016-07-27 EP disclosed
EP-2369921-B1 STABLE SULFOXIMINE-INSECTICIDE COMPOSITIONS DOW AGROSCIENCES LLC (US) 2016-07-27 EP disclosed
EP-2369921-B1 STABLE SULFOXIMINE-INSECTICIDE COMPOSITIONS DOW AGROSCIENCES LLC (US) 2016-07-27 EP disclosed
EP-2369935-B1 STABLE INSECTICIDE COMPOSITIONS AND METHODS FOR PRODUCING SAME DOW AGROSCIENCES LLC (US) 2016-07-27 EP disclosed
US-9125412-B2 Stable insecticide compositions and methods for producing same DOW AGROSCIENCES LLC (US) 2015-09-08 US disclosed
US-9125412-B2 Stable insecticide compositions and methods for producing same DOW AGROSCIENCES LLC (US) 2015-09-08 US disclosed
US-9012654-B2 Insecticidal N-substituted (6-haloalkylpyridin-3-yl)-alkyl sulfoximines DOW AGROSCIENCES LLC (US) 2015-04-21 US disclosed
WO-2009014891-A2 INCREASING PLANT VIGOR DOW AGROSCIENCES LLC (US) 2009-01-29 WO disclosed
US-20090023782-A1 INCREASING PLANT VIGOR DOW AGROSCIENCES LLC (IN) 2009-01-22 US disclosed
US-20090023782-A1 INCREASING PLANT VIGOR DOW AGROSCIENCES LLC (IN) 2009-01-22 US disclosed
US-20090023782-A1 INCREASING PLANT VIGOR DOW AGROSCIENCES LLC (IN) 2009-01-22 US disclosed
EP-1989184-A2 INSECTICIDAL N-SUBSTITUTED (6-HALOALKYLPYRIDIN-3-YL)ALKYL SULFOXIMINES Dow AgroSciences LLC (US) 2008-11-12 EP disclosed
US-20070203191-A1 Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines CORTEVA AGRISCIENCE LLC 2007-08-30 US disclosed
US-20070203191-A1 Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines CORTEVA AGRISCIENCE LLC 2007-08-30 US disclosed
US-20070203191-A1 Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines CORTEVA AGRISCIENCE LLC 2007-08-30 US disclosed
WO-2007095229-A2 INSECTICIDAL N-SUBSTITUTED (6-HALOALKYLPYRIDIN-3-YL)ALKYL SULFOXIMINES DOW AGROSCIENCES LLC (US) 2007-08-23 WO disclosed
WO-2007095229-A2 INSECTICIDAL N-SUBSTITUTED (6-HALOALKYLPYRIDIN-3-YL)ALKYL SULFOXIMINES DOW AGROSCIENCES LLC (US) 2007-08-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023782-A1 INCREASING PLANT VIGOR HDLBP, VPS4B, VPS28 CDK2 2195/4885CDK9 1056/4885HDAC6 2422/4885
US-20070203191-A1 Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines NPEPPS, PRDX6, HDHD5 CDK2 4345/4885CDK9 4545/4885HDAC6 326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.