Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 5/20 | 0.36 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579371 | 0.84 | ALDH1A1 (0.41) | SMN1; SMN2DHFRADORA2AADORA2BTLR8 | |
| SCHEMBL16441111 | 0.81 | SMN1; SMN2 (0.37) | SMN1; SMN2HSP90AB1ADORA2AADORA2BTLR8 | |
| SCHEMBL23513918 | 0.77 | KCNH2 (0.34) | SMN1; SMN2ADORA2AADORA2B | |
| SCHEMBL23513916 | 0.76 | DCPS (0.35) | SMN1; SMN2DHFRDCPSHSP90AB1HSD17B10 | |
| SCHEMBL18312205 | 0.76 | IKBKB (0.53) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30808060 | 0.76 | IKBKB (0.53) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30092898 | 0.76 | DHFR (0.37) | SMN1; SMN2DHFRDCPSTLR8TLR7 | |
| SCHEMBL23500886 | 0.73 | TLR8 (0.40) | DHFRTLR8TLR7 | |
| SCHEMBL23500389 | 0.72 | DHFR (0.37) | DHFRTLR8TLR7 | |
| SCHEMBL20665353 | 0.70 | L3MBTL1 (0.47) | SMN1; SMN2ADORA2AADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822347-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | Janssen Sciences Ireland Unlimited Company (IE) | 2020-11-03 | — | — | US | disclosed |
| US-20190330227-A1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330227-A1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | TYMS, TYMP, UMPS | SMN1; SMN2 1618/4885DHFR 63/4885DCPS 170/4885 |
| US-10822347-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | TYMS, TYMP, UMPS | SMN1; SMN2 1618/4885DHFR 63/4885DCPS 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.