SCHEMBL2154228

SCHEMBL2154228

O=C(Cl)c1ccc2c(C(=O)Cl)cccc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.61
ALDH1A1 P00352 5/20 0.43
HPGD P15428 2/20 0.43
MAPT P10636 1/20 0.43
NR4A1 P22736 1/20 0.41
NR4A2 P43354 1/20 0.41
NR4A3 Q92570 1/20 0.41
KDM4E B2RXH2 1/20 0.41
GAA P10253 1/20 0.41
SLC9A1 P19634 1/20 0.40
TSHR P16473 1/20 0.40
ALOX15 P16050 1/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
MMP3 P08254 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
PLA2G2D Q9UNK4 1/20 0.37
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 P62805 1/20 0.37
EP300 Q09472 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31625685 1.00 PTPN1 (0.61) PTPN1ALDH1A1HPGDMAPTNR4A1
SCHEMBL18153975 0.86 CES2 (0.50) PTPN1ALDH1A1HPGDMAPTNR4A1
SCHEMBL2154707 0.85 PLA2G2D (0.51) PTPN1ALDH1A1HPGDMAPTNR4A1
SCHEMBL23909525 0.84 PTPN1 (0.51) PTPN1ALDH1A1HPGDMAPTKDM4E
SCHEMBL30362287 0.84 PTPN1 (0.51) PTPN1ALDH1A1HPGDMAPTKDM4E
SCHEMBL23909591 0.84 LCK (0.54) PTPN1ALDH1A1HPGDMAPTKDM4E
SCHEMBL29860832 0.82 ALDH1A1 (0.57) PTPN1ALDH1A1HPGDNR4A1NR4A2
SCHEMBL4607123 0.82 ALDH1A1 (0.57) PTPN1ALDH1A1HPGDNR4A1NR4A2
SCHEMBL3917253 0.81 PLAU (0.52) PTPN1ALDH1A1HPGDMAPTPLAU
SCHEMBL6604497 0.81 PTPN1 (0.47) PTPN1ALDH1A1NR4A1NR4A2NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106661245-B Method for producing film and method for storing coating liquid 住友化学株式会社 2020-08-21 CN disclosed
US-10730819-B2 Naphthalenedicarboxylic acid dichloride production method KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2020-08-04 US disclosed
CN-111039779-A Process for producing naphthalenedicarboxylic dichloride 京瓷办公信息系统株式会社 2020-04-21 CN disclosed
US-20200115313-A1 NAPHTHALENEDICARBOXYLIC ACID DICHLORIDE PRODUCTION METHOD KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2020-04-16 US disclosed
EP-3184171-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2019-03-20 EP disclosed
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-12-04 US disclosed
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP 2017-10-26 US disclosed
US-9732106-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2017-08-15 US disclosed
EP-3184171-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS Chevron Phillips Chemical Company LP (US) 2017-06-28 EP disclosed
EP-2519532-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2017-03-08 EP disclosed
EP-0643039-A1 Ultraviolet ray-absorbing aromatic compound and polymeric composition containing the same TEIJIN LIMITED (JP) 1995-03-15 EP disclosed
US-5312851-A Benzene and naphthalene containing polyamides with terminal imide groups TEIJIN LIMITED (JP) 1994-05-17 US disclosed
US-5233013-A Thermotropic liquid-crystalline aromatic coplymers ENICHEM S.P.A. (IT) 1993-08-03 US disclosed
EP-0552499-A2 Wholly aromatic polyamide resin composition having enhanced light resistance TEIJIN LIMITED (JP) 1993-07-28 EP disclosed
US-5155204-A Polyesters and polylactones; heat stability ENICHEM S.P.A. (IT) 1992-10-13 US disclosed
EP-0375036-A1 Thermotropic liquid-crystalline aromatic copolymers ENICHEM S.p.A. (IT) 1990-06-27 EP disclosed
EP-0005858-B1 PREPARATION OF POLYARYLATES UNION CARBIDE CORPORATION (US) 1983-05-11 EP disclosed
US-4229565-A BY FORMATION OF THE ACYL CHLORIDE THEN POLYMERIZING TO FORM HIGH MOLECULAR WEIGHT, HEAT RESISTANT POLYESTERS UNION CARBIDE CORPORATION (US) 1980-10-21 US disclosed
EP-0005858-A1 Preparation of polyarylates UNION CARBIDE CORPORATION (US) 1979-12-12 EP disclosed
US-4018735-A Anisotropic dopes of aromatic polyamides TEIJIN LIMITED (JA) 1977-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins NIT2, NCLN, NPM1 PTPN1 1741/4885ALDH1A1 4849/4885HPGD 3570/4885
US-20200115313-A1 NAPHTHALENEDICARBOXYLIC ACID DICHLORIDE PRODUCTION METHOD DDT, DHODH, DLD PTPN1 4001/4885ALDH1A1 786/4885HPGD 45/4885
US-10730819-B2 Naphthalenedicarboxylic acid dichloride production method DDT, DHODH, DLD PTPN1 4001/4885ALDH1A1 786/4885HPGD 45/4885
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 PTPN1 1741/4885ALDH1A1 4849/4885HPGD 3570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.