SCHEMBL2154707

SCHEMBL2154707

O=C(Cl)c1ccc2cccc(C(=O)Cl)c2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G2D Q9UNK4 1/20 0.51
PLAU P00749 3/20 0.50
PTPN1 P18031 3/20 0.43
NR4A1 P22736 1/20 0.41
NR4A2 P43354 1/20 0.41
NR4A3 Q92570 1/20 0.41
ALDH1A1 P00352 5/20 0.41
KDM4E B2RXH2 1/20 0.41
GAA P10253 1/20 0.41
HPGD P15428 2/20 0.40
MTNR1A P48039 1/20 0.40
TSHR P16473 1/20 0.40
MAPT P10636 1/20 0.40
F2 P00734 1/20 0.40
PLG P00747 1/20 0.40
PLAT P00750 1/20 0.40
KLK1 P06870 1/20 0.40
PRSS1 P07477 1/20 0.40
ALOX15 P16050 1/20 0.38
CES2 O00748 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18153975 0.86 CES2 (0.50) PLAUPTPN1NR4A1NR4A2NR4A3
SCHEMBL2154228 0.85 PTPN1 (0.61) PLA2G2DPLAUPTPN1NR4A1NR4A2
SCHEMBL31625685 0.85 PTPN1 (0.61) PLA2G2DPLAUPTPN1NR4A1NR4A2
SCHEMBL23909574 0.84 PLAU (0.47) PLA2G2DPLAUALDH1A1KDM4EGAA
SCHEMBL30362194 0.84 NQO2 (0.47) PLA2G2DPLAUALDH1A1KDM4EGAA
SCHEMBL23909536 0.84 NQO2 (0.47) PLA2G2DPLAUALDH1A1KDM4EGAA
SCHEMBL4607123 0.82 ALDH1A1 (0.57) PLA2G2DPLAUPTPN1NR4A1NR4A2
SCHEMBL29860832 0.82 ALDH1A1 (0.57) PLA2G2DPLAUPTPN1NR4A1NR4A2
SCHEMBL3923684 0.81 PTPN1 (0.48) PTPN1KDM4EMTNR1AMAPTTRPV1
SCHEMBL11148876 0.81 ALDH1A1 (0.55) ALDH1A1KDM4EHPGDTSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106661245-B Method for producing film and method for storing coating liquid 住友化学株式会社 2020-08-21 CN disclosed
US-10730819-B2 Naphthalenedicarboxylic acid dichloride production method KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2020-08-04 US disclosed
CN-111039779-A Process for producing naphthalenedicarboxylic dichloride 京瓷办公信息系统株式会社 2020-04-21 CN disclosed
US-20200115313-A1 NAPHTHALENEDICARBOXYLIC ACID DICHLORIDE PRODUCTION METHOD KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2020-04-16 US disclosed
EP-3184171-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2019-03-20 EP disclosed
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-12-04 US disclosed
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP 2017-10-26 US disclosed
US-9732106-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2017-08-15 US disclosed
EP-3184171-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS Chevron Phillips Chemical Company LP (US) 2017-06-28 EP disclosed
EP-2519532-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2017-03-08 EP disclosed
US-20160168180-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP 2016-06-16 US disclosed
US-9283555-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2016-03-15 US disclosed
US-20140221645-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2014-08-07 US disclosed
US-8680003-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2014-03-25 US disclosed
US-20120309965-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-12-06 US disclosed
EP-2519532-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS Chevron Phillips Chemical Company LP (US) 2012-11-07 EP disclosed
WO-2011082192-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins NIT2, NCLN, NPM1 PLA2G2D 108/4885PLAU 1297/4885PTPN1 1741/4885
US-20200115313-A1 NAPHTHALENEDICARBOXYLIC ACID DICHLORIDE PRODUCTION METHOD DDT, DHODH, DLD PLA2G2D 2418/4885PLAU 2871/4885PTPN1 4001/4885
US-20120309965-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 PLA2G2D 108/4885PLAU 1297/4885PTPN1 1741/4885
US-20160168180-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 PLA2G2D 108/4885PLAU 1297/4885PTPN1 1741/4885
US-10730819-B2 Naphthalenedicarboxylic acid dichloride production method DDT, DHODH, DLD PLA2G2D 2418/4885PLAU 2871/4885PTPN1 4001/4885
US-20140221645-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 PLA2G2D 108/4885PLAU 1297/4885PTPN1 1741/4885
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 PLA2G2D 108/4885PLAU 1297/4885PTPN1 1741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.