Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15648793 | 0.80 | ALDH1A1 (0.62) | PLA2G2AALDH1A1L3MBTL1HPGDNPC1 | |
| SCHEMBL18856329 | 0.78 | PLA2G2A (0.48) | RORCPLA2G2ATLR8GRM1ALDH1A1 | |
| SCHEMBL28158605 | 0.77 | RORC (0.45) | RORCPLA2G2ATLR8ALDH1A1HPGD | |
| SCHEMBL16461497 | 0.74 | PLA2G2A (0.49) | RORCPLA2G2ATLR8GRM1ALDH1A1 | |
| SCHEMBL16462216 | 0.71 | RORC (0.55) | RORCPLA2G2ATLR8GRM1ALDH1A1 | |
| SCHEMBL21574677 | 0.70 | PKM (0.45) | RORCPLA2G2AALDH1A1L3MBTL1POLB | |
| SCHEMBL21382648 | 0.66 | HDAC1 (0.55) | ALDH1A1HPGDNPC1CYP1A2CYP2C19 | |
| SCHEMBL21574740 | 0.65 | HTT (0.51) | PLA2G2ATLR8ALDH1A1POLBKMT2A | |
| SCHEMBL78217 | 0.65 | CES2 (0.52) | L3MBTL1HPGD | |
| SCHEMBL21574658 | 0.64 | PKM (0.58) | RORCPLA2G2AALDH1A1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909192-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-17 | — | — | EP | disclosed |