SCHEMBL215780

SCHEMBL215780

OB(O)c1cccc(Cl)c1O

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
ALDH1A1 P00352 3/20 0.39
HSP90AA1 P07900 1/20 0.37
ENPP2 Q13822 2/20 0.37
IDO1 P14902 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2A6 P11509 1/20 0.36
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4991 0.78 TSHR (0.48) TSHRALDH1A1ENPP2CYP1A2CYP2A6
SCHEMBL29352520 0.78 TSHR (0.48) TSHRALDH1A1ENPP2CYP1A2CYP2A6
SCHEMBL4129 0.77 TSHR (0.47) TSHRALDH1A1ENPP2LMNA
SCHEMBL29404220 0.77 TSHR (0.47) TSHRALDH1A1ENPP2LMNA
SCHEMBL28937384 0.77 ALDH1A1 (0.54) TSHRALDH1A1CYP1A2CYP2A6
SCHEMBL28963359 0.77 CYP1A2 (0.50) TSHRALDH1A1CYP1A2CYP2A6
2,6-Dichlorophenol SCHEMBL8986495 0.76 TSHR (0.50) TSHRALDH1A1HSP90AA1IDO1CYP1A2
SCHEMBL1772196 0.76 ALDH1A1 (0.48) TSHRALDH1A1ENPP2CYP1A2CYP2A6
2,6-Dichlorophenol SCHEMBL65234 0.76
SCHEMBL132727 0.75 ALDH1A1 (0.55) ALDH1A1ENPP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-11-27 US disclosed
US-20250359473-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERAL DISPLAY CORPORATION (US) 2025-11-20 US disclosed
US-12453280-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2025-10-21 US disclosed
EP-4446327-B1 COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME LG CHEMICAL LTD (KR) 2025-09-24 EP disclosed
US-12404253-B2 2,4,6-trisubstituted 1,3,5-triazines as modulators of CX3CR1 ASTRAZENECA AB (SE) 2025-09-02 US disclosed
EP-4605388-A1 <SUP2/>? <SUB2/>?3?2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CXCR1 Astrazeneca AB (SE) 2025-08-27 EP disclosed
EP-4254527-B1 ORGANIC LIGHT EMITTING DEVICE LG CHEMICAL LTD (KR) 2025-07-30 EP disclosed
EP-4587127-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE Prelude Therapeutics Incorporated (US) 2025-07-23 EP disclosed
US-20250170248-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-05-29 US disclosed
WO-2025101738-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE PRELUDE THERAPEUTICS INCORPORATED (US) 2025-05-15 WO disclosed
US-20140131663-A1 Iridium Complexes With Aza-Benzo Fused Ligands UNIVERSAL DISPLAY CORPORATION (US) 2014-05-15 US disclosed
US-20140131663-A1 Iridium Complexes With Aza-Benzo Fused Ligands UNIVERSAL DISPLAY CORPORATION (US) 2014-05-15 US disclosed
US-20140131676-A1 IRIDIUM COMPLEXES WITH AZA-BENZO FUSED LIGANDS UNIVERSAL DISPLAY CORPORATION (US) 2014-05-15 US disclosed
US-20140131663-A1 Iridium Complexes With Aza-Benzo Fused Ligands UNIVERSAL DISPLAY CORPORATION (US) 2014-05-15 US disclosed
EP-2730583-A1 Iridium complexes with aza-benzo fused ligands Universal Display Corporation (US) 2014-05-14 EP disclosed
EP-2730583-A1 Iridium complexes with aza-benzo fused ligands Universal Display Corporation (US) 2014-05-14 EP disclosed
US-8507512-B2 Soluble guanylate cyclase activators MERCK SHARP & DOHME CORP. (US) 2013-08-13 US disclosed
EP-2401265-A2 SOLUBLE GUANYLATE CYCLASE ACTIVATORS Merck Sharp & Dohme Corp. (US) 2012-01-04 EP disclosed
WO-2010099054-A2 SOLUBLE GUANYLATE CYCLASE ACTIVATORS MERCK SHARP & DOHME CORP. (US) 2010-09-02 WO disclosed
US-20100216764-A1 Soluble Guanylate Cyclase Activators MERCK SHARP & DOHME LLC 2010-08-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12404253-B2 2,4,6-trisubstituted 1,3,5-triazines as modulators of CX3CR1 CX3CR1, CCR2, CCR5 TSHR 1113/4885ALDH1A1 1531/4885HSP90AA1 2175/4885
US-20250170248-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCA2, SMARCC2 TSHR 4388/4885ALDH1A1 2230/4885HSP90AA1 1539/4885
US-12453280-B2 Organic electroluminescent materials and devices OCIAD1, OCIAD2, OSBP TSHR 4121/4885ALDH1A1 434/4885HSP90AA1 3875/4885
US-20250359473-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, OSBP TSHR 4128/4885ALDH1A1 497/4885HSP90AA1 3877/4885
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK TSHR 3739/4885ALDH1A1 4095/4885HSP90AA1 1695/4885
US-20100216764-A1 Soluble Guanylate Cyclase Activators GUCY1B1, GUCY1A1, GUCY1A2 TSHR 1172/4885ALDH1A1 1356/4885HSP90AA1 2617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.