Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 15/20 | 0.37 |
| ▸ | GABRD | O14764 | 15/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 15/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 15/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 15/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 15/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 15/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 15/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 15/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 15/20 | 0.37 |
| ▸ | GABRE | P78334 | 15/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 15/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 15/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 15/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 15/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30254275 | 1.00 | GLA (0.38) | GLAPOLBGAATSHRGABRP | |
| SCHEMBL24312075 | 0.79 | KDM4E (0.34) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8339116 | 0.78 | GABRP (0.35) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19349268 | 0.75 | GAA (0.42) | GLAPOLBGAATSHRKDM4E | |
| SCHEMBL29455898 | 0.75 | GAA (0.42) | GLAPOLBGAATSHRKDM4E | |
| SCHEMBL4022880 | 0.74 | GLA (0.38) | GLAPOLBGAATSHRTP53 | |
| SCHEMBL21031807 | 0.74 | GLA (0.45) | GLAPOLBGAATSHRPIK3CD | |
| SCHEMBL29601287 | 0.74 | GLA (0.45) | GLAPOLBGAATSHRPIK3CD | |
| SCHEMBL8342407 | 0.73 | VNN1 (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3971495 | 0.72 | NOS3 (0.37) | POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810609-B1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-06-12 | — | — | EP | disclosed |
| CN-112601747-B | Pyrazole derivatives as MALT1 inhibitors | 詹森药业有限公司 | 2023-02-21 | — | — | CN | disclosed |
| EP-3810609-A1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2021-04-28 | — | — | EP | disclosed |
| CN-112601747-A | Pyrazole derivatives as MALT1 inhibitors | 詹森药业有限公司 | 2021-04-02 | — | — | CN | disclosed |
| US-10888550-B2 | Pyrazole derivatives as MALT1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-01-12 | — | — | US | disclosed |
| US-10888550-B2 | Pyrazole derivatives as MALT1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-01-12 | — | — | US | disclosed |
| WO-2019243965-A1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243965-A1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10888550-B2 | Pyrazole derivatives as MALT1 inhibitors | MALT1, PPP3R1, SQSTM1 | GLA 2624/4885POLB 4389/4885GAA 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.