Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780155 | 1.00 | HTT (0.42) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL2298978 | 0.90 | HTT (0.41) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL2161654 | 0.82 | GRM2 (0.36) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL21780072 | 0.82 | GRM2 (0.36) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL12239929 | 0.82 | HTT (0.43) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL24969604 | 0.81 | SLC22A2 (0.39) | LMNAGRM2GLRA1S1PR5 | |
| SCHEMBL21780077 | 0.79 | ALDH1A1 (0.41) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL24969606 | 0.79 | SLC22A2 (0.41) | HTTMEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL21780078 | 0.78 | HTT (0.40) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL12239939 | 0.78 | HTT (0.39) | HTTSMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617194-B1 | PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS | VIIV HEALTHCARE CO (US) | 2023-11-08 | — | — | EP | disclosed |
| EP-2376453-B1 | INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS | VIIV HEALTHCARE CO (US) | 2019-11-20 | — | — | EP | disclosed |
| US-9707246-B2 | Substituted (3S,11AR)-N-[(2,4-difluorophenyl)methyl]-6-oxy-3-methyl-5,7-dioxo-2,3,5,7,11,11A-hexahydro[1,3]oxazolo[3,2-A]pyrido[1,2-D]pyrazine-8-carboxamides as HIV agents | SHIONOGI & CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| US-9707246-B2 | Substituted (3S,11AR)-N-[(2,4-difluorophenyl)methyl]-6-oxy-3-methyl-5,7-dioxo-2,3,5,7,11,11A-hexahydro[1,3]oxazolo[3,2-A]pyrido[1,2-D]pyrazine-8-carboxamides as HIV agents | SHIONOGI & CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| US-9707246-B2 | Substituted (3S,11AR)-N-[(2,4-difluorophenyl)methyl]-6-oxy-3-methyl-5,7-dioxo-2,3,5,7,11,11A-hexahydro[1,3]oxazolo[3,2-A]pyrido[1,2-D]pyrazine-8-carboxamides as HIV agents | SHIONOGI & CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| EP-2660239-B1 | CHEMICAL COMPOUNDS AS SYNTHETIC INTERMEDIATES | VIIV HEALTHCARE CO (US) | 2016-11-23 | — | — | EP | disclosed |
| US-9365587-B2 | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates | SHIONOGI & CO., LTD. (JP) | 2016-06-14 | — | — | US | disclosed |
| US-20160060274-A1 | SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES | VIIV HEALTHCARE COMPANY (US) | 2016-03-03 | — | — | US | disclosed |
| US-9242986-B2 | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates | SHIONOGI & CO., LTD. (JP) | 2016-01-26 | — | — | US | disclosed |
| EP-2320909-B1 | CHEMICAL COMPOUNDS | VIIV HEALTHCARE CO (US) | 2016-01-06 | — | — | EP | disclosed |
| US-20140031555-A1 | CHEMICAL COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 2014-01-30 | — | — | US | disclosed |
| US-20140031555-A1 | CHEMICAL COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 2014-01-30 | — | — | US | disclosed |
| US-8624023-B2 | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates | SHIONOGI & CO., LTD. (JP) | 2014-01-07 | — | — | US | disclosed |
| US-8580967-B2 | Methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate and processes for the preparation thereof | SHIONOGI & CO., LTD. (JP) | 2013-11-12 | — | — | US | disclosed |
| US-8580967-B2 | Methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate and processes for the preparation thereof | SHIONOGI & CO., LTD. (JP) | 2013-11-12 | — | — | US | disclosed |
| EP-2660239-A1 | Chemical compounds as synthetic intermediates | VIIV Healthcare Company (US) | 2013-11-06 | — | — | EP | disclosed |
| US-8552187-B2 | Processes and intermediates for carbamoylpyridone HIV integrase inhibitors | SHIONOGI & CO., LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| US-20110263855-A1 | PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS | SHIONOGI & CO., LTD. (JP) | 2011-10-27 | — | — | US | disclosed |
| US-20110183940-A1 | CHEMICAL COMPOUNDS | VIIV HEALTHCARE COMPANY | 2011-07-28 | — | — | US | disclosed |
| US-20110183940-A1 | CHEMICAL COMPOUNDS | VIIV HEALTHCARE COMPANY | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263855-A1 | PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS | INTS6, IDH1, OPRM1 | HTT 3454/4885SMN1; SMN2 4105/4885MEN1 3483/4885 |
| US-20110183940-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | HTT 3836/4885SMN1; SMN2 4798/4885MEN1 4686/4885 |
| US-20160060274-A1 | SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES | IL2, QPCT, IL4I1 | HTT 4316/4885SMN1; SMN2 4799/4885MEN1 4203/4885 |
| US-20140031555-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | HTT 3836/4885SMN1; SMN2 4798/4885MEN1 4686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.