SCHEMBL21611730

SCHEMBL21611730

COc1cc(-c2ccc(N=NC3C(=O)N(c4ccc(C)cc4)N=C3C)c(OC)c2)ccc1N=NC1C(=O)N(c2ccc(C)cc2)N=C1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 14/20 0.52
▸ MEN1 O00255 13/20 0.52
▸ ATM Q13315 1/20 0.52
▸ MAPT P10636 10/20 0.50
▸ ALDH1A1 P00352 7/20 0.50
▸ SMN1; SMN2 Q16637 6/20 0.50
▸ NPC1 O15118 5/20 0.50
▸ RAB9A P51151 5/20 0.50
▸ TDP1 Q9NUW8 3/20 0.50
▸ MAPK1 P28482 3/20 0.50
▸ LMNA P02545 3/20 0.50
▸ XBP1 P17861 1/20 0.46
▸ CTDSP1 Q9GZU7 1/20 0.46
▸ POLB P06746 3/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.46
▸ CYP1A2 P05177 2/20 0.43
▸ GAA P10253 1/20 0.43
▸ CYP2D6 P10635 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29355605 0.92 KMT2A (0.62) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL9451197 0.92 KMT2A (0.62) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL9228544 0.84 MAPT (0.52) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL29356536 0.84 MAPT (0.52) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL2449957 0.84 MAPT (0.52) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL2388626 0.80 KMT2A (0.67) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL30215701 0.80 KMT2A (0.67) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL9231057 0.78 PDE4A (0.49) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL21436310 0.76 GAA (0.44) KMT2AMEN1ATMMAPTALDH1A1
SCHEMBL29351685 0.76 GAA (0.44) KMT2AMEN1ATMMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230310300-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER HFC PRESTIGE SERVICE GERMINY GMBH (DE) 2023-10-05 — — US disclosed
EP-4171500-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER Wella Germany GmbH (DE) 2023-05-03 — — EP disclosed
US-11324688-B2 Bicomponent composition WELLA INTERNATIONAL OPERATIONS SWI (CH) 2022-05-10 — — US disclosed
US-20220054392-A1 MULTICOMPONENT IN SITU COLORATION COMPOSITION WELLA INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2022-02-24 — — US disclosed
US-20220016017-A1 COLOR COATINGS WITH DOWNSTREAM FEATURES HFC PRESTIGE SERVICE GERMANY GMBH (DE) 2022-01-20 — — US disclosed
WO-2022002983-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER HFC PRESTIGE SERVICE GERMANY GMBH (DE) 2022-01-06 — — WO disclosed
EP-3890683-A1 MULTICOMPONENT IN SITU COLORATION COMPOSITION HFC Prestige International Holding Switzerland S.a.r.l. (CH) 2021-10-13 — — EP disclosed
US-20210290519-A1 MULTICOMPONENT SILICONE COMPOSITION WELLA INT OPERATIONS SWITZERLAND SARL (CH) 2021-09-23 — — US disclosed
US-20210290518-A1 MULTICOMPONENT COMPOSITION HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) 2021-09-23 — — US disclosed
US-20210145726-A1 BICOMPONENT COMPOSITION HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2021-05-20 — — US disclosed
EP-3817710-A1 MULTICOMPONENT SILICONE COMPOSITION HFC Prestige International Holding Switzerland S.a.r.l. (CH) 2021-05-12 — — EP disclosed
WO-2020114647-A1 MULTICOMPONENT IN SITU COLORATION COMPOSITION HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) 2020-06-11 — — WO disclosed
WO-2020007511-A1 MULTICOMPONENT SILICONE COMPOSITION HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) 2020-01-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220016017-A1 COLOR COATINGS WITH DOWNSTREAM FEATURES KRT18, ITGA5, FLNA KMT2A 586/4885MEN1 2431/4885ATM 3344/4885
US-20230310300-A1 HAIR COLOURING COMPOSITIONS COMPRISING A BIO-BASED POLYMER AND A CROSSLINKER KRT18, MKI67, IK KMT2A 876/4885MEN1 811/4885ATM 2106/4885
US-20210290519-A1 MULTICOMPONENT SILICONE COMPOSITION CUTA, CD99, PLOD3 KMT2A 648/4885MEN1 10/4885ATM 1552/4885
US-20220054392-A1 MULTICOMPONENT IN SITU COLORATION COMPOSITION KRT18, PRKDC, VIM KMT2A 1653/4885MEN1 1309/4885ATM 3230/4885
US-11324688-B2 Bicomponent composition KRT18, EXOSC10, EXOSC9 KMT2A 1253/4885MEN1 1869/4885ATM 963/4885
US-20210290518-A1 MULTICOMPONENT COMPOSITION KRT18, INCENP, IK KMT2A 684/4885MEN1 585/4885ATM 3120/4885
US-20210145726-A1 BICOMPONENT COMPOSITION KRT18, EXOSC10, EXOSC9 KMT2A 1253/4885MEN1 1869/4885ATM 963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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