SCHEMBL21628575

SCHEMBL21628575

CCOC(=O)c1ccc(Oc2ccc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)c(F)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.40
KDM4E B2RXH2 3/20 0.40
MAPK1 P28482 1/20 0.40
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
HSD17B2 P37059 1/20 0.39
LMNA P02545 2/20 0.39
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
IGFBP3 P17936 1/20 0.39
POLB P06746 2/20 0.38
KMT2A Q03164 1/20 0.38
GAA P10253 1/20 0.38
ICAM1 P05362 1/20 0.37
SELE P16581 1/20 0.37
PDK1 Q15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21628863 0.97 MAPT (0.41) MAPTKDM4EMAPK1CA12CA1
SCHEMBL21628422 0.92 IGFBP3 (0.42) MAPTKDM4EMAPK1CA12CA1
SCHEMBL21628909 0.87 ALDH1A1 (0.48) MAPTKDM4EMAPK1CA1CA2
SCHEMBL21628636 0.87 MAPT (0.42) MAPTKDM4EMAPK1CA12CA1
SCHEMBL21656741 0.87 MAPT (0.49) MAPTKDM4EMAPK1CA12CA1
SCHEMBL21656818 0.86 CA12 (0.46) MAPTKDM4EMAPK1CA12CA1
SCHEMBL19357358 0.85 ALDH1A1 (0.50) MAPTKDM4EMAPK1CA12CA1
SCHEMBL21628705 0.84 ALDH1A1 (0.49) MAPTKDM4EMAPK1CA1CA2
SCHEMBL21628455 0.83 LMNA (0.48) MAPTKDM4EMAPK1LMNAIGFBP3
SCHEMBL21628387 0.82 PARP10 (0.50) MAPTKDM4EIGFBP3KMT2AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-12-21 US disclosed
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-05-18 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2022-11-03 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK MAPT 2272/4885KDM4E 143/4885MAPK1 3508/4885
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK MAPT 2272/4885KDM4E 143/4885MAPK1 3508/4885
US-11591289-B2 Aromatic compounds AHR, TYR, MUSK MAPT 2195/4885KDM4E 152/4885MAPK1 3401/4885
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK MAPT 2272/4885KDM4E 143/4885MAPK1 3508/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR MAPT 4404/4885KDM4E 1660/4885MAPK1 2406/4885
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK MAPT 2272/4885KDM4E 143/4885MAPK1 3508/4885
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK MAPT 2272/4885KDM4E 143/4885MAPK1 3508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.