Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3295364 | 0.72 | ALDH1A1 (0.38) | NPSR1ALDH1A1KDM4EGAARXRA | |
| SCHEMBL8931196 | 0.70 | ALDH1A1 (0.35) | ALDH1A1KDM4EGAARXRARXRB | |
| SCHEMBL30434458 | 0.69 | ALDH1A1 (0.35) | PPARAALDH1A1KDM4EGAARXRA | |
| SCHEMBL706844 | 0.68 | RIPK1 (0.35) | PPARA | |
| SCHEMBL28634307 | 0.67 | ALDH1A1 (0.49) | RBP4NPSR1ALDH1A1KDM4EGAA | |
| SCHEMBL9698448 | 0.67 | LTB4R (0.47) | NPSR1PPARAALDH1A1KDM4EGAA | |
| SCHEMBL7910681 | 0.66 | LTA4H (0.46) | ALDH1A1MAPTHDAC6 | |
| SCHEMBL864473 | 0.65 | LTA4H (0.47) | ALDH1A1HPGD | |
| SCHEMBL3298464 | 0.65 | ALDH1A1 (0.43) | NPSR1ALDH1A1KDM4EGAARXRA | |
| Propionic Acid SCHEMBL28419513 | 0.65 | ALDH1A1 (0.48) | RBP4NPSR1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228376-B1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | KITASATO INST (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-8519128-B2 | Pyripyropene derivatives having an ACAT2-inhibiting activity | THE KITASATO INSTITUTE (JP) | 2013-08-27 | — | — | US | disclosed |
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | disclosed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | ACAT2, ACAT1, AGPAT2 | RBP4 768/4885NPSR1 3321/4885PPARA 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.