Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL218691 | 0.90 | ENPP3 (0.31) | ALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL216563 | 0.86 | ENPP3 (0.33) | ALDH1A1KDM4EHPGDMAPTTDP2 | |
| Hydrochloric Acid SCHEMBL2114523 | 0.81 | DHFR (0.36) | ALDH1A1KDM4EHPGDMAPTTDP2 | |
| Hydrochloric Acid SCHEMBL7212490 | 0.78 | ALDH1A1 (0.33) | ALDH1A1KDM4EHPGDMAPTTDP2 | |
| Hydrochloric Acid SCHEMBL4482816 | 0.78 | KDM1A (0.33) | ALDH1A1KDM4EHPGDMAPTTDP2 | |
| Hydrochloric Acid SCHEMBL7933100 | 0.78 | KDM1A (0.33) | ALDH1A1KDM4EHPGDMAPTTDP2 | |
| Hydrochloric Acid SCHEMBL3765255 | 0.78 | KDM1A (0.33) | ALDH1A1KDM4EHPGDMAPTTDP2 | |
| Hydrochloric Acid SCHEMBL7926729 | 0.78 | ALDH1A1 (0.33) | ALDH1A1KDM4EHPGDCYP2A6DHFR | |
| Hydrochloric Acid SCHEMBL7933040 | 0.78 | ENPP3 (0.32) | ALDH1A1KDM4EHPGDCYP2A6DHFR | |
| Hydrochloric Acid SCHEMBL7939134 | 0.77 | ENPP3 (0.31) | ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957159-B2 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2015-02-17 | — | — | US | disclosed |
| US-20140066567-A1 | Multiple Catalyst System for Olefin Polymerization and Polymers Produced Therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2014-03-06 | — | — | US | disclosed |
| US-8563647-B2 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2013-10-22 | — | — | US | disclosed |
| EP-1558655-B1 | MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM | EXXONMOBIL CHEM PATENTS INC (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20120095157-A1 | Multiple Catalyst System For Olefin Polymerization And Polymers Produced Therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2012-04-19 | — | — | US | disclosed |
| US-8088867-B2 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8071687-B2 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-7662895-B2 | comprising polypropylene which is produced in presence of a metallocene transition metal catalyst and an activator; peak melting point temperature below about 110 degrees C., a tensile set of 40% or less, and greater than or equal to about 60% [r]dyads | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090069475-A1 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2009-03-12 | — | — | US | disclosed |
| US-20070293640-A1 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2007-12-20 | — | — | US | disclosed |
| US-7294681-B2 | Mutliple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-11-13 | — | — | US | disclosed |
| US-7223822-B2 | Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20070117941-A1 | Syndiotactic propylene elastomers | EXXONMOBIL CHEMICAL PATENTS INC. | 2007-05-24 | — | — | US | disclosed |
| EP-1753796-A1 | MULTIPLE CATALYST AND REACTOR SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM | ExxonMobil Chemical Patents, Inc., A Corporation of the State of Delaware (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113622-A1 | MULTIPLE CATALYST AND REACTOR SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2005-12-01 | — | — | WO | disclosed |
| EP-1558655-A2 | MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM | Exxonmobil Chemical Patents Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040220359-A1 | Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-11-04 | — | — | US | disclosed |
| US-20040138392-A1 | polyolefin adhesives; to produce reactor blends (also called intimate blends) of various polymers and other polymer compositions. | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004046214-A2 | MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-06-03 | — | — | WO | disclosed |