Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166261 | 0.82 | HSP90AA1 (0.46) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2166868 | 0.81 | ALDH1A1 (0.37) | MAPTHPGDKDM4EMEN1CYP3A4 | |
| SCHEMBL2165459 | 0.80 | CA12 (0.45) | MAPTKDM4ENFKB1CA1CA2 | |
| SCHEMBL2167928 | 0.77 | PLK1 (0.42) | MAPTHPGDNPC1RAB9AMEN1 | |
| Paraben SCHEMBL27590290 | 0.75 | CA2 (0.67) | MAPTHPGDALOX15SMN1; SMN2TDP1 | |
| SCHEMBL2167670 | 0.75 | KDM4E (0.41) | MAPTHPGDKDM4ENFKB1SMN1; SMN2 | |
| SCHEMBL2166808 | 0.73 | CES2 (0.47) | MAPTHPGDKDM4EMEN1CYP3A4 | |
| SCHEMBL2166642 | 0.72 | CA1 (0.38) | MAPTHPGDNPC1KDM4EMEN1 | |
| SCHEMBL2164877 | 0.72 | CES2 (0.48) | MAPTHPGDNPC1RAB9AKDM4E | |
| SCHEMBL2164763 | 0.71 | CES2 (0.45) | HPGDNPC1RAB9ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350036-B1 | METHYLENE FURANONE DERIVATIVES AND USE OF SAID DERIVATIVES AS A PHOTOPROTECTING OR ANTIOXIDANT OR DEPIGMENTATION AGENT IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS | PIERRE FABRE DERMO COSMÉTIQUE (FR) | 2015-04-15 | — | — | EP | claimed |
| US-8563548-B2 | Methylene furanone derivatives and use of said derivatives as a photoprotecting or antioxidant or depigmentation agent in cosmetic or dermatological compositions | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2013-10-22 | — | — | US | claimed |
| US-20110184059-A1 | METHYLENE FURANONE DERIVATIVES AND USE OF SAID DERIVATIVES AS A PHOTOPROTECTING OR ANTIOXIDANT OR DEPIGMENTATION AGENT IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2011-07-28 | — | — | US | claimed |
| WO-2010034827-A1 | METHYLENE FURANONE DERIVATIVES AND USE OF SAID DERIVATIVES AS A PHOTOPROTECTING OR ANTIOXIDANT OR DEPIGMENTATION AGENT IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2010-04-01 | — | — | WO | claimed |
| EP-2350036-B1 | METHYLENE FURANONE DERIVATIVES AND USE OF SAID DERIVATIVES AS A PHOTOPROTECTING OR ANTIOXIDANT OR DEPIGMENTATION AGENT IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS | PIERRE FABRE DERMO COSMÉTIQUE (FR) | 2015-04-15 | — | — | EP | disclosed |
| US-8563548-B2 | Methylene furanone derivatives and use of said derivatives as a photoprotecting or antioxidant or depigmentation agent in cosmetic or dermatological compositions | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2013-10-22 | — | — | US | disclosed |
| US-20110184059-A1 | METHYLENE FURANONE DERIVATIVES AND USE OF SAID DERIVATIVES AS A PHOTOPROTECTING OR ANTIOXIDANT OR DEPIGMENTATION AGENT IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184059-A1 | METHYLENE FURANONE DERIVATIVES AND USE OF SAID DERIVATIVES AS A PHOTOPROTECTING OR ANTIOXIDANT OR DEPIGMENTATION AGENT IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS | NQO1, ESD, DHPS | MAPT 4045/4885HPGD 138/4885NPC1 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.